LOV2-Controlled Photoactivation of Protein Trans-Splicing.
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DOI: 10.1007/978-1-4939-6451-2_15
Abstract: Protein trans-splicing is a posttranslational modification that joins two protein fragments together via a peptide a bond in a process that does not require exogenous cofactors. Towards achieving cellular control, synthetically engineered systems have used… read more here.
Keywords: protein; controlled photoactivation; lov2 controlled; protein trans ... See more keywords
Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system
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DOI: 10.1038/s41598-017-08641-3
Abstract: Many methods have been developed to produce bispecific antibodies (BsAbs) for industrial application. However, huge challenges still remain in synthesizing whole length BsAbs, including their assembly, stability, immunogenicity, and pharmacodynamics. Here we present for first… read more here.
Keywords: bispecific igg; split intein; protein trans; igg antibodies ... See more keywords