Restoring functional neurofibromin by protein transduction
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DOI: 10.1038/s41598-018-24310-5
Abstract: In Neurofibromatosis 1 (NF1) germ line loss of function mutations result in reduction of cellular neurofibromin content (NF1+/−, NF1 haploinsufficiency). The Ras-GAP neurofibromin is a very large cytoplasmic protein (2818 AA, 319 kDa) involved in the… read more here.
Keywords: neurofibromin; functional neurofibromin; protein transduction; restoring functional ... See more keywords
Newly designed Protein Transduction Domain (PTD)‐mediated BMP‐7 is a potential therapeutic for peritoneal fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15992
Abstract: While the bone morphogenetic protein‐7 (BMP‐7) is a well‐known therapeutic growth factor reverting many fibrotic diseases, including peritoneal fibrosis by peritoneal dialysis (PD), soluble growth factors are largely limited in clinical applications owing to their… read more here.
Keywords: peritoneal fibrosis; bmp; protein transduction; ptd ... See more keywords
Inactivation of HIV-1 in Polarized Infant Tonsil Epithelial Cells by Human Beta-Defensins 2 and 3 Tagged with the Protein Transduction Domain of HIV-1 Tat
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13102043
Abstract: Mother-to-child transmission (MTCT) of HIV-1 may occur during pregnancy, labor, and breastfeeding; however, the molecular mechanism of MTCT of virus remains poorly understood. Infant tonsil mucosal epithelium may sequester HIV-1, serving as a transient reservoir,… read more here.
Keywords: epithelial cells; hiv; protein transduction; beta defensins ... See more keywords