mTOR signaling regulates Zika virus replication bidirectionally through autophagy and protein translation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28422
Abstract: Zika virus (ZIKV) reemerged in 2016 and attracted much more attention worldwide. To date, the limited knowledge of ZIKV interactions with host cells in the early stages of infection impedes the prevention of viral epidemics… read more here.
Keywords: protein translation; mtor signaling; autophagy protein; zikv ... See more keywords
CDK Phosphorylation of Translation Initiation Factors Couples Protein Translation with Cell-Cycle Transition
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.063
Abstract: SUMMARY Protein translation in eukaryotes is cell-cycle dependent, with translation rates more robust in G1 phase of the cell cycle than in mitosis. However, whether the fundamental cell-cycle control machinery directly activates protein translation during… read more here.
Keywords: cycle transition; translation; protein translation; cell cycle ... See more keywords
The regulation of protein translation and its implications for cancer
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00444-9
Abstract: In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected to… read more here.
Keywords: implications cancer; regulation protein; translation; protein translation ... See more keywords
A dual-reporter system for investigating and optimizing protein translation and folding in E. coli.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26337-1
Abstract: Strategies for investigating and optimizing the expression and folding of proteins for biotechnological and pharmaceutical purposes are in high demand. Here, we describe a dual-reporter biosensor system that simultaneously assesses in vivo protein translation and… read more here.
Keywords: reporter; system; reporter system; protein translation ... See more keywords
Sepsis halts renal protein translation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-018-0104-5
Abstract: Sepsis can cause multiple organ failure and is associated with high patient mortality, but how is sepsis linked to widespread organ damage? Takashi hato, Pierre Dagher and colleagues now report that bacterial sepsis triggers a… read more here.
Keywords: sepsis; organ failure; translation; protein translation ... See more keywords
Invasive lobular and ductal breast carcinoma differ in immune response, protein translation efficiency and metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25357-0
Abstract: Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer following invasive ductal carcinoma (IDC). ILC differs from IDC in a number of histological and clinical features, such as single strand… read more here.
Keywords: carcinoma; metabolism; invasive lobular; protein translation ... See more keywords
Methods for monitoring and measurement of protein translation in time and space
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biosystems"
DOI: 10.1039/c7mb00476a
Abstract: Regulation of protein translation constitutes a crucial step in control of gene expression. Here we review recent methods for system-wide monitoring and measurement of protein translation. read more here.
Keywords: protein; monitoring measurement; protein translation; measurement protein ... See more keywords
Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac580
Abstract: Abstract Tandem repeats of guanine-rich sequences in RNA often form thermodynamically stable four-stranded RNA structures. Such RNA G-quadruplexes have long been considered to be linked to essential biological processes, yet their physiological significance in cells… read more here.
Keywords: rna quadruplex; protein translation; rna; modulate protein ... See more keywords
PO-108 FKBP10 is an oncofetal protein that supports lung cancer growth by promoting protein translation elongation
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.149
Abstract: Introduction Cancer therapy is limited by lack of specificity. Thus, identifying molecules that are relevant for tumorigenesis and selectively expressed by cancer cells is of paramount medical importance. Here, following computational and immunohistological analyses, we… read more here.
Keywords: fkbp10; protein translation; lung cancer; cancer ... See more keywords
PARK2 Regulates eIF4B-Driven Lymphomagenesis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-21-0729
Abstract: Abstract Patients with high-risk diffuse large B-cell lymphoma have poor outcomes following first-line cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab (R-CHOP); thus, treatment of this fatal disease remains an area of unmet medical need and requires… read more here.
Keywords: park2 regulates; lymphomagenesis; protein translation; park2 ... See more keywords
Gene regulation by a protein translation factor at the single-cell level
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010087
Abstract: Gene expression is inherently stochastic and pervasively regulated. While substantial work combining theory and experiments has been carried out to study how noise propagates through transcriptional regulations, the stochastic behavior of genes regulated at the… read more here.
Keywords: cell; protein translation; translation factor; gene ... See more keywords