Activation of Engineered Protein Tyrosine Phosphatases with the Biarsenical Compound AsCy3‐EDT2
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700253
Abstract: Methods for activating signaling enzymes hold significant potential for the study of cellular signal transduction. Here we present a strategy for engineering chemically activatable protein tyrosine phosphatases (actPTPs). To generate actPTP1B, we introduced three cysteine… read more here.
Keywords: tyrosine phosphatases; ascy3 edt2; wpd loop; protein tyrosine ... See more keywords
Label‐Free Detection of Protein Tyrosine Phosphatase 1B (PTP1B) by Using a Rationally Designed Förster Resonance Energy Transfer (FRET) Probe
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DOI: 10.1002/cbic.201800529
Abstract: A highly selective detection method of native protein tyrosine phosphatase 1B (PTP1B) is described using a target specific probe equipped with 1‐naphthylamine (λex=330 nm, λem=445 nm). Irradiation of a mixture of PTP1B and Probe 1 with ultraviolet light… read more here.
Keywords: detection; probe; tyrosine phosphatase; protein tyrosine ... See more keywords
Mapping the Chemical Space of Active‐Site Targeted Covalent Ligands for Protein Tyrosine Phosphatases **
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200706
Abstract: Protein tyrosine phosphatases (PTPs) are an important class of enzymes that modulate essential cellular processes through protein dephosphorylation and are dysregulated in various disease states. There is demand for new compounds that target the active… read more here.
Keywords: protein tyrosine; mapping chemical; space active; tyrosine phosphatases ... See more keywords
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB Life"
DOI: 10.1002/iub.2716
Abstract: In October 2020, we were finally able to gather for a celebration of Eddy Fischer's 100th birthday. As with many other events, COVID had disrupted and restricted preparations for the gathering, which ultimately was held… read more here.
Keywords: protein tyrosine; phosphatases mighty; tyrosine phosphatases; mighty oaks ... See more keywords
Nonreceptor protein tyrosine phosphatases (NRPTPs) gene family associates with the risk of hepatocellular carcinoma in a Chinese hepatitis B virus‐related subjects
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DOI: 10.1002/mc.23228
Abstract: Nonreceptor protein tyrosine phosphatases (NRPTPs) are reported to be associated with several human cancers, but their roles in hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) remain unclear. Here, we integrated bioinformatics tools, population association analyses,… read more here.
Keywords: risk; hcc; tyrosine phosphatases; hbv ... See more keywords
Protein tyrosine phosphatase nonreceptor type 2 exerts antimetastatic functions in pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23554
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive tumor with a dismal prognosis. Recent studies have demonstrated PTPN2 (protein tyrosine phosphatase nonreceptor type 2) as a potential target for cancer therapy. However, the functions of… read more here.
Keywords: protein tyrosine; nonreceptor type; phosphatase nonreceptor; ductal adenocarcinoma ... See more keywords
Determination of the Inhibitory Activity of Ferula sinkiangensis Polysaccharides for Protein Tyrosine Phosphatase 1B
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-019-02657-z
Abstract: Polysaccharide fractions were sequentially extracted in 28.86 wt% yield from roots of Ferula sinkiangensis K. M. Shen. The polysaccharide fractions from F. sinkiangensis were identified as heteropolysaccharides and contained primarily the monosaccharides glucuronic and galacturonic… read more here.
Keywords: ferula sinkiangensis; polysaccharide fractions; tyrosine phosphatase; protein tyrosine ... See more keywords
Protein tyrosine phosphatases in cardiac physiology and pathophysiology
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DOI: 10.1007/s10741-018-9676-1
Abstract: More than any other organ, the heart is particularly sensitive to gene expression deregulation, often leading in the long run to impaired contractile performances and excessive fibrosis deposition progressing to heart failure. Recent investigations provide… read more here.
Keywords: heart; tyrosine phosphatases; protein tyrosine; pathophysiology ... See more keywords
Discovery of inhibitors targeting protein tyrosine phosphatase 1B using a combined virtual screening approach.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10323-2
Abstract: Protein tyrosine phosphatase 1B (PTP1B) acts as a therapeutic target for type 2 diabetes. However, the major challenges of PTP1B drug discovery are the poor selectivity and the weak oral bioavailability. In this study, we… read more here.
Keywords: virtual screening; tyrosine phosphatase; combined virtual; protein tyrosine ... See more keywords
Exploration of Zinc(II) Complexes as Potent Inhibitors Against Protein Tyrosine Phosphatase 1B
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-019-8265-8
Abstract: Although protein tyrosine phosphatases(PTPs) do not contain any metals, their activities can be inhibited by some metal complexes. Here we investigated the inhibition of two zinc complexes with Schiff base ligands against PTPs activity to… read more here.
Keywords: phosphatase; tyrosine phosphatase; zinc complexes; protein tyrosine ... See more keywords
Luteinizing hormone modulates intracellular calcium, protein tyrosine phosphorylation and motility during human sperm capacitation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.010
Abstract: In order to fertilize, spermatozoa must undergo physiological and biochemical changes during their transit along the female reproductive tract before reaching and fusing with the oocyte, process known as capacitation. Sperm modifications associated with capacitation… read more here.
Keywords: hormone; capacitation; protein tyrosine; motility ... See more keywords