Structural basis of generic versus specific E2–RING E3 interactions in protein ubiquitination
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3690
Abstract: Protein ubiquitination is a fundamental regulatory component in eukaryotic cell biology, where a cascade of ubiquitin activating (E1), conjugating (E2), and ligating (E3) enzymes assemble distinct ubiquitin signals on target proteins. E2s specify the type… read more here.
Keywords: structural basis; basis generic; generic versus; protein ubiquitination ... See more keywords
Proteomic and Biochemical Analyses Reveal a Novel Mechanism for Promoting Protein Ubiquitination and Degradation by UFBP1, a Key Component of Ufmylation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.7b00843
Abstract: Protein post-translational modification by ubiquitin-fold modifier 1, UFM1, regulates many biological processes such as response to endoplasmic reticulum stress and regulation of tumor progression. A recent study has indicated that the UFM1-binding and PCI domain-containing… read more here.
Keywords: degradation; mechanism; protein ubiquitination; interacting proteins ... See more keywords
Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76239-3
Abstract: eIF2α phosphorylation-mediated translational regulation is crucial for global translation repression by various stresses, including the unfolded protein response (UPR). However, translational control during UPR has not been demonstrated in yeast. This study investigated ribosome ubiquitination-mediated… read more here.
Keywords: protein ubiquitination; stress; translation; ribosomal protein ... See more keywords
LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination
Sign Up to like & getrecommendations! Published in 2021 at "Virulence"
DOI: 10.1080/21505594.2021.1948261
Abstract: ABSTRACT Zika virus (ZIKV) infection can cause severe neurological disorders, including Guillain–Barre syndrome and meningoencephalitis in adults and microcephaly in fetuses. Here, we reveal that laminin receptor 1 (LAMR1) is a novel host resistance factor… read more here.
Keywords: protein; protein ubiquitination; infection; lamr1 ... See more keywords
Probing protein ubiquitination in live cells
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac805
Abstract: The reversible attachment of ubiquitin governs the interaction, activity and degradation of proteins whereby the type and target of this conjugation determine the biological response. The investigation of this complex and multi-faceted protein ubiquitination mostly… read more here.
Keywords: ubiquitination live; live cells; protein ubiquitination; ubiquitination ... See more keywords
Protein ubiquitination in plant peroxisomes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13346
Abstract: Protein ubiquitination regulates diverse cellular processes in eukaryotic organisms, from growth and development to stress response. Proteins subjected to ubiquitination can be found in virtually all subcellular locations and organelles, including peroxisomes-single-membrane and highly dynamic… read more here.
Keywords: ubiquitination plant; protein ubiquitination; plant; ubiquitination ... See more keywords
A Novel Luminescence-Based High-Throughput Approach for Cellular Resolution of Protein Ubiquitination Using Tandem Ubiquitin Binding Entities (TUBEs)
Sign Up to like & getrecommendations! Published in 2020 at "SLAS Discovery"
DOI: 10.1177/2472555219901261
Abstract: Protein turnover is highly regulated by the posttranslational process of ubiquitination. Deregulation of the ubiquitin proteasome system (UPS) has been implicated in cancer and neurodegenerative diseases, and modulating this system has proven to be a… read more here.
Keywords: protein ubiquitination; high throughput; ubiquitination; approach ... See more keywords
Prediction of Protein Ubiquitination Sites in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2019 at "Current Bioinformatics"
DOI: 10.2174/1574893614666190311141647
Abstract: As one of the most important reversible protein post-translation modification types, ubiquitination plays a significant role in the regulation of many biological processes, such as cell division, signal transduction, apoptosis and immune response. Protein ubiquitination… read more here.
Keywords: ubiquitination sites; protein ubiquitination; thaliana; prediction ... See more keywords
Protein ubiquitination in T cell development
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.941962
Abstract: As an important form of posttranslational modification, protein ubiquitination regulates a wide variety of biological processes, including different aspects of T cell development and differentiation. During T cell development, thymic seeding progenitor cells (TSPs) in… read more here.
Keywords: cell development; development; protein ubiquitination; ubiquitination cell ... See more keywords
Regulation of AMPA Receptor Trafficking by Protein Ubiquitination
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00347
Abstract: The molecular mechanisms underlying plastic changes in the strength and connectivity of excitatory synapses have been studied extensively for the past few decades and remain the most attractive cellular models of learning and memory. One… read more here.
Keywords: regulation ampa; protein ubiquitination; ampa; ampa receptor ... See more keywords