Polyamines interfere with protein ubiquitylation and cause depletion of intracellular amino acids: a possible mechanism for cell growth inhibition
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13299
Abstract: Spermidine is a polyamine present in eukaryotes with essential functions in protein synthesis. At high concentrations spermidine and norspermidine inhibit growth by unknown mechanisms. Transcriptomic analysis of the effect of norspermidine on the plant Arabidopsis… read more here.
Keywords: amino acids; protein ubiquitylation; growth inhibition; depletion ... See more keywords
Analysis of defective protein ubiquitylation associated to adriamycin resistant cells
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DOI: 10.1080/15384101.2017.1387694
Abstract: ABSTRACT DNA damage activated by Adriamycin (ADR) promotes ubiquitin–proteasome system-mediated proteolysis by stimulating both the activity of ubiquitylating enzymes and the proteasome. In ADR-resistant breast cancer MCF7 (MCF7ADR) cells, protein ubiquitylation is significantly reduced compared… read more here.
Keywords: analysis defective; mcf7adr cells; ubiquitylation; protein ubiquitylation ... See more keywords
UbiComb: A Hybrid Deep Learning Model for Predicting Plant-Specific Protein Ubiquitylation Sites
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DOI: 10.3390/genes12050717
Abstract: Protein ubiquitylation is an essential post-translational modification process that performs a critical role in a wide range of biological functions, even a degenerative role in certain diseases, and is consequently used as a promising target… read more here.
Keywords: protein; ubiquitylation; protein ubiquitylation; deep learning ... See more keywords