A General Protein Unfolding‐Chemical Coupling Strategy for Pure Protein Hydrogels with Mechanically Strong and Multifunctional Properties
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202102557
Abstract: Protein‐based hydrogels have attracted great attention due to their excellent biocompatible properties, but often suffer from weak mechanical strength. Conventional strengthening strategies for protein‐based hydrogels are to introduce nanoparticles or synthetic polymers for improving their… read more here.
Keywords: strength; strategy; pure protein; protein unfolding ... See more keywords
Initial Protein Unfolding Events in Ubiquitin, Cytochrome c and Myoglobin Are Revealed with the Use of 213 nm UVPD Coupled to IM-MS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1007/s13361-018-1992-0
Abstract: AbstractThe initial stages of protein unfolding may reflect the stability of the entire fold and can also reveal which parts of a protein can be perturbed, without restructuring the rest. In this work, we couple… read more here.
Keywords: ubiquitin cytochrome; initial protein; protein unfolding; cytochrome myoglobin ... See more keywords
Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains?
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2016.12.002
Abstract: Extracellular matrix fibrils of fibronectin (FN) are highly elastic, and are typically stretched three to four times their relaxed length. The mechanism of stretching has been controversial, in particular whether it involves tension-induced unfolding of… read more here.
Keywords: unfold fniii; fniii domains; protein unfolding; force ... See more keywords
Direct Experimental Evidence of Surface-induced Protein Unfolding at the Single-molecule Level
Sign Up to like & getrecommendations! Published in 2020 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927620014178
Abstract: Protein unfolding, i.e. the loss of its native tertiary (quaternary) structure, is a part of many important biological processes [1,2] and plays a big role in various biomedical and biotechnological applications [3,4]. Protein unfolding may… read more here.
Keywords: microscopy; surface; surface induced; level ... See more keywords
Linking Gas-Phase and Solution-Phase Protein Unfolding via Mobile Proton Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c03352
Abstract: Native mass spectrometry coupled to ion mobility (IM-MS) combined with collisional activation (CA) of ions in the gas phase (in vacuo) is an important method for the study of protein unfolding. It has advantages over… read more here.
Keywords: mobile proton; gas phase; protein unfolding; solution phase ... See more keywords
Control of Nanoscale In Situ Protein Unfolding Defines Network Architecture and Mechanics of Protein Hydrogels
Sign Up to like & getrecommendations! Published in 2021 at "ACS Nano"
DOI: 10.1021/acsnano.1c00353
Abstract: Hierarchical assemblies of proteins exhibit a wide-range of material properties that are exploited both in nature and by artificially by humankind. However, little is understood about the importance of protein unfolding on the network assembly,… read more here.
Keywords: protein; architecture mechanics; network; protein unfolding ... See more keywords
A wrinkled nanosurface causes accelerated protein unfolding revealing its critical role in nanotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra05489b
Abstract: Wrinkles are often found to have a strong influence on the properties of nanomaterials and have attracted extensive research interest. However, the consequences of the use of wrinkled nanomaterials in biological systems remain largely unknown.… read more here.
Keywords: wrinkle corner; causes accelerated; nanosurface causes; accelerated protein ... See more keywords
Protein Unfolding—Thermodynamic Perspectives and Unfolding Models
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065457
Abstract: Protein unfolding is a dynamic cooperative process with many short-lived intermediates. Cooperativity means that similar molecular elements act dependently on each other. The thermodynamics of protein unfolding can be determined with differential scanning calorimetry (DSC).… read more here.
Keywords: heat capacity; protein unfolding; two state; model ... See more keywords
Chetaev Instability Framework for Kinetostatic Compliance-Based Protein Unfolding
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Control Systems Letters"
DOI: 10.48550/arxiv.2205.07375
Abstract: Understanding the process of protein unfolding plays a crucial role in various applications such as design of folding-based protein engines. Using the well-established kinetostatic compliance (KCM)-based method for modeling of protein conformation dynamics and a… read more here.
Keywords: instability framework; kinetostatic compliance; chetaev instability; protein unfolding ... See more keywords