APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8.
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DOI: 10.1172/jci.insight.92581
Abstract: APOL1 variants in African populations mediate resistance to trypanosomal infection but increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in glomerular podocytes and does not vary with underlying kidney disease diagnoses or… read more here.
Keywords: protein; protein vamp8; apol1 variants; apol1 ... See more keywords