α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production
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DOI: 10.1007/s00401-017-1704-z
Abstract: Abstractα-Synuclein is strongly linked to Parkinson’s disease but the molecular targets for its toxicity are not fully clear. However, many neuronal functions damaged in Parkinson’s disease are regulated by signalling between the endoplasmic reticulum (ER)… read more here.
Keywords: protein; protein vapb; vapb; parkinson disease ... See more keywords