Proteinase activated receptor‐2 counterbalances the vascular effects of endothelin‐1 in fibrotic tight‐skin mice
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DOI: 10.1111/bph.13618
Abstract: The majority of the severe vascular complications in fibrosis are a consequence of a deregulated activity of mediators controlling vasomotor tone. One of the most important of these mediators is endothelin‐1 (ET‐1). Here, we have… read more here.
Keywords: activated receptor; tight skin; proteinase activated;
Heat shock protein‐27 and sex‐selective regulation of muscarinic and proteinase‐activated receptor 2‐mediated vasodilatation: differential sensitivity to endothelial NOS inhibition
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14200
Abstract: Previously, we demonstrated that exogenous heat shock protein 27 (HSP27/gene, HSPB1) treatment of human endothelial progenitor cells (EPCs) increases the synthesis and secretion of VEGF, improves EPC‐migration/re‐endothelialization and decreases neo‐intima formation, suggesting a role for… read more here.
Keywords: endothelial nos; heat shock; activated receptor; shock protein ... See more keywords
Proteinase‐activated receptor 1: A target for repurposing in the treatment of COVID‐19?
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DOI: 10.1111/bph.15194
Abstract: In the search to rapidly identify effective therapies that will mitigate the morbidity and mortality of COVID‐19, attention has been directed towards the repurposing of existing drugs. Candidates for repurposing include drugs that target COVID‐19… read more here.
Keywords: treatment covid; activated receptor; proteinase activated;
The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease
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DOI: 10.1155/2017/5193572
Abstract: Proteinase-activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial… read more here.
Keywords: tissue metabolism; periodontal tissue; proteinase; activated receptors ... See more keywords
Microenvironment proteinases, proteinase-activated receptor regulation, cancer and inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Biological Chemistry"
DOI: 10.1515/hsz-2018-0001
Abstract: Abstract We propose that in the microenvironment of inflammatory tissues, including tumours, extracellular proteinases can modulate cell signalling in part by regulating proteinase-activated receptors (PARs). We have been exploring this mechanism in a variety of… read more here.
Keywords: microenvironment proteinases; inflammation; inflammatory; proteinase activated ... See more keywords
Proteinase Activated Receptors Mediate the Trypsin-Induced Ca2 + Signaling in Human Uterine Epithelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.709902
Abstract: Embryo implantation is a complex and tightly regulated process. In humans, uterine luminal epithelium functions as a biosensor gauging the embryo quality and transmitting this information to the underlying endometrial stromal cells. This quality control… read more here.
Keywords: mediate trypsin; trypsin; activated receptors; human uterine ... See more keywords
Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling
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DOI: 10.3390/ijms18112494
Abstract: The G protein-coupled receptor proteinase-activated receptor 2 (PAR2) has been implicated in various aspects of cellular physiology including inflammation, obesity and cancer. In cancer, it usually acts as a driver of cancer progression in various… read more here.
Keywords: cancer; activated receptor; tgf signaling; proteinase activated ... See more keywords