Antipsychotic clozapine binding to alpha-2-macroglobulin protects interacting partners against oxidation and preserves the anti-proteinase activity of the protein.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.04.155
Abstract: In this study, the interaction between clozapine, an atypical antipsychotic drug, and alpha-2-macroglobulin (α2M), a multipurpose anti-proteinase, was investigated under simulated (patho) physiological conditions using multiple spectroscopic techniques and molecular modeling. It was found that… read more here.
Keywords: proteinase activity; anti proteinase; clozapine; alpha macroglobulin ... See more keywords
Testing the influence of surfactant‐based wound dressings on proteinase activity
Sign Up to like & getrecommendations! Published in 2017 at "International Wound Journal"
DOI: 10.1111/iwj.12697
Abstract: Proteinases are enzymes that can digest other proteins. In chronic wounds, a sub‐class of these enzymes with the ability to degrade the extracellular matrix (matrix metalloproteinases, MMPs) have been found to both inhibit healing and… read more here.
Keywords: collagenase; surfactant based; proteinase activity; surfactant ... See more keywords