Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids
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DOI: 10.1002/cmdc.202000940
Abstract: Antimicrobial peptides (AMPs) are potential novel therapeutic drugs against microbial infections. Most AMPs function by disrupting microbial membranes because of their amphipathic properties and ordered secondary structures. In this minireview, we describe recent efforts to… read more here.
Keywords: proteinogenic amino; amino; amino acids; foldamers containing ... See more keywords
Syntone chemistry and prebiotic stage in life evolution 1. Aziridinone, a key compound in formation of the first proteinogenic amino acids and polypeptides
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Astrobiology"
DOI: 10.1017/s1473550417000301
Abstract: Abstract In this paper is proposed a new theory concerning the formation of the first proteinogenic amino acids and their corresponding polypeptides starting of three syntones: methylene, nitrene and carbon monoxide. First, at low temperature… read more here.
Keywords: proteinogenic amino; acids polypeptides; amino acids; chemistry ... See more keywords
Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis.
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DOI: 10.1021/acschembio.2c00823
Abstract: (2,6)-Diamino-(5,7)-dihydroxyheptanoic acid (DADH), a non-proteinogenic amino acid, is converted to 1-azabicyclo[3.1.0]hexane ring-containing amino acids that are subsequently incorporated into ficellomycin and vazabitide A. The present study revealed that the sugar aminotransferase-like enzymes Fic25 and Vzb9,… read more here.
Keywords: amino acids; proteinogenic amino; sugar aminotransferase; stereochemistry ... See more keywords
Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures
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DOI: 10.1038/nchem.2703
Abstract: A central problem for the prebiotic synthesis of biological amino acids and nucleotides is to avoid the concomitant synthesis of undesired or irrelevant by-products. Additionally, multistep pathways require mechanisms that enable the sequential addition of… read more here.
Keywords: proteinogenic amino; amino; amino acids; prebiotic selection ... See more keywords
Crystal structures of non-proteinogenic amino acid peroxosolvates: rare example of H-bonded hydrogen peroxide chains
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DOI: 10.1039/c8ce01486h
Abstract: Novel peroxosolvates of the non-proteinogenic amino acids sarcosine C3H7NO2·H2O2 (1) and phenylserine C9H11NO3·H2O2 (2) were prepared and their structures were determined by X-ray crystallography. All «active» hydrogen atoms (amino, hydroxo, and peroxo) in these adducts… read more here.
Keywords: proteinogenic amino; amino; amino acid; acid peroxosolvates ... See more keywords
In the Pursuit of (Ald)Imine Surrogates for the Direct Asymmetric Synthesis of Non-Proteinogenic α-Amino Acids
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DOI: 10.1055/a-1463-4266
Abstract: Nature remarkably employs posttranslational modifications of the 20 canonical α-amino acids to devise a far larger structural, conformational, and functional diversity found in non-proteinogenic amino acids (NPAAs), which ultimately translates into a plethora of complex… read more here.
Keywords: synthesis; asymmetric synthesis; amino acids; proteinogenic amino ... See more keywords
A Plausible Entry to 20 Proteinogenic Amino Acids via Aminomalononitrile Derivatives
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DOI: 10.1177/1934578x231175261
Abstract: Dear Editor, It is not yet known why the number of proteinogenic amino acids is limited to 20. Some explanations for this problem have been attempted, but it is still unresolved. Aminomalononitrile is a hydrogen… read more here.
Keywords: amino acids; proteinogenic amino; phe tyr; side ... See more keywords