Concise enantioselective synthesis of non-proteinogenic α-aminoacids via an organocatalytic Mannich-type reaction.
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DOI: 10.1039/d2cc04909k
Abstract: A bifunctional tertiary amine-squaramide-catalyzed enantioselective Mannich-type addition of available allomaltol to N-protected aldimines was developed. The resulted adducts were readily transformed into non-proteinogenic α-amino acids and their derivatives were not easily accessible by other methods… read more here.
Keywords: enantioselective synthesis; proteinogenic aminoacids; synthesis non; concise enantioselective ... See more keywords