Drugging the undruggable proteins in cancer: A systems biology approach.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.07.004
Abstract: In recent years, the research community has, with comprehensive systems biology approaches and related technologies, gained insight into the vast complexity of numerous cancers. These approaches allow an in-depth exploration that cannot be achieved solely… read more here.
Keywords: proteins cancer; drugging undruggable; biology; systems biology ... See more keywords
Polyphenol-Assisted Biomineralization of Metal-Organic Framework Nanoparticles for Precision Delivery of Therapeutic Proteins to Cancer Cells.
Sign Up to like & getrecommendations! Published in 2024 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.4c00154
Abstract: The delivery of proteins into the cytosol holds great promise for cell signaling manipulation and the development of precision medicine. However, this potency is challenged by achieving targeted and controlled delivery, specifically within diseased cells.… read more here.
Keywords: cancer; cancer cells; precision; delivery ... See more keywords
Highlight: RNA-binding proteins in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aap9424
Abstract: ADAR promotes lung adenocarcinoma migration and invasion through stabilization of FAK. ADAR promotes lung adenocarcinoma migration and invasion through stabilization of FAK. read more here.
Keywords: proteins cancer; rna binding; highlight rna; binding proteins ... See more keywords
Role of exosomal proteins in cancer diagnosis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer"
DOI: 10.1186/s12943-017-0706-8
Abstract: Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-sized vesicle secreted by various living cells in all body fluids. Based on the expanding albeit incomplete knowledge of their biogenesis,… read more here.
Keywords: proteins cancer; cancer diagnosis; role exosomal; cancer ... See more keywords
Pleiotropic Actions of PGRMC Proteins in Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac078
Abstract: Progesterone receptor membrane component (PGRMC) proteins play important roles in tumor growth, progression and chemoresistance of which PGRMC1 is the best characterized. The ancestral member predates the evolution of metazoans, so it is perhaps not… read more here.
Keywords: proteins cancer; pgrmc proteins; pleiotropic actions; actions pgrmc ... See more keywords
Chromobox proteins in cancer: Multifaceted functions and strategies for modulation (Review)
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Oncology"
DOI: 10.3892/ijo.2023.5484
Abstract: Chromobox (CBX) proteins are important epigenetic regulatory proteins and are widely involved in biological processes, such as embryonic development, the maintenance of stem cell characteristics and the regulation of cell proliferation and apoptosis. Disorder and… read more here.
Keywords: review; proteins cancer; cancer multifaceted; chromobox proteins ... See more keywords
The meaning of PIWI proteins in cancer development
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.5932
Abstract: Cancer is a histologically and genetically heterogeneous population of tumor cells that exhibits distinct molecular profiles determined by epigenetic alterations. P-element-induced wimpy testis (PIWI) proteins in complex with PIWI-interacting RNA (piRNA) have been previously demonstrated… read more here.
Keywords: cancer; proteins cancer; cancer development; piwi proteins ... See more keywords