Vav family proteins constitute disparate branching points for distinct BCR signaling pathways
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DOI: 10.1002/eji.202048621
Abstract: Antigen recognition by B‐cell antigen receptors (BCRs) activates distinct intracellular signaling pathways that control the differentiation fate of activated B lymphocytes. BCR‐proximal signaling enzymes comprise protein tyrosine kinases, phosphatases, and plasma membrane lipid‐modifying enzymes, whose… read more here.
Keywords: signaling pathways; family; constitute disparate; proteins constitute ... See more keywords
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
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DOI: 10.1038/s41467-018-03131-0
Abstract: Aggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs are unique within a proteome,… read more here.
Keywords: aggregation; many proteins; sequences occur; occur many ... See more keywords