Accumulation of “Old Proteins” and the Critical Need for MS‐based Protein Turnover Measurements in Aging and Longevity
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DOI: 10.1002/pmic.201800403
Abstract: Aging and age‐related diseases are accompanied by proteome remodeling and progressive declines in cellular machinery required to maintain protein homeostasis (proteostasis), such as autophagy, ubiquitin‐mediated degradation, and protein synthesis. While many studies have focused on… read more here.
Keywords: protein; protein turnover; accumulation old; proteins critical ... See more keywords
Intrinsically Disordered Proteins: Critical Components of the Wetware.
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DOI: 10.1021/acs.chemrev.1c00848
Abstract: Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since their discovery, there are several aspects that remain unexplored and, hence, poorly understood. A living cell is a complex adaptive system that can… read more here.
Keywords: critical components; cell; components wetware; intrinsically disordered ... See more keywords