Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16335-0
Abstract: Mitochondrial aging, which results in mitochondrial dysfunction, is strongly linked to many age-related diseases. Aging is associated with mitochondrial enlargement and transport of cytosolic proteins into mitochondria. The underlying homeostatic mechanisms that regulate mitochondrial morphology… read more here.
Keywords: protein; proteins mitochondria; age; transport ... See more keywords
Interaction of misfolded proteins and mitochondria in neurodegenerative disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20170024
Abstract: The number of the people affected by neurodegenerative disorders is growing dramatically due to the ageing of population. The major neurodegenerative diseases share some common pathological features including the involvement of mitochondria in the mechanism… read more here.
Keywords: proteins mitochondria; amyloid tau; neurodegenerative disorders; tau synuclein ... See more keywords
Newly imported proteins in mitochondria are particularly sensitive to aggregation.
Sign Up to like & getrecommendations! Published in 2023 at "Acta physiologica"
DOI: 10.1111/apha.13985
Abstract: AIM A functional proteome is essential for life and maintained by protein quality control (PQC) systems in the cytosol and organelles. Protein aggregation is an indicator of a decline of PQC linked to aging and… read more here.
Keywords: aggregation; newly imported; particularly sensitive; microscopy ... See more keywords