Behaviour of intrinsically disordered proteins in protein–protein complexes with an emphasis on fuzziness
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2560-7
Abstract: Intrinsically disordered proteins (IDPs) do not, by themselves, fold into a compact globular structure. They are extremely dynamic and flexible, and are typically involved in signalling and transduction of information through binding to other macromolecules.… read more here.
Keywords: proteins protein; protein protein; binding; behaviour intrinsically ... See more keywords
Cellular Delivery of Large Functional Proteins and Protein-Nucleic Acid Constructs via Localized Electroporation.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c04374
Abstract: Delivery of proteins and protein-nucleic acid constructs into live cells enables a wide range of applications from gene editing to cell-based therapies and intracellular sensing. However, electroporation-based protein delivery remains challenging due to the large… read more here.
Keywords: electroporation; localized electroporation; protein nucleic; nucleic acid ... See more keywords
The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01289
Abstract: Progress toward new antidepressant therapies has been relatively slow over the past few decades, with the result that individuals suffering from depression often struggle to find an effective treatment – a process often requiring months.… read more here.
Keywords: protein regulating; regulating proteins; proteins protein; role ... See more keywords
The Role of Small Heat Shock Proteins in Protein Misfolding Associated Motoneuron Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911759
Abstract: Motoneuron diseases (MNDs) are neurodegenerative conditions associated with death of upper and/or lower motoneurons (MNs). Proteostasis alteration is a pathogenic mechanism involved in many MNDs and is due to the excessive presence of misfolded and… read more here.
Keywords: motoneuron diseases; heat shock; role; heat ... See more keywords
Theater in the Self-Cleaning Cell: Intrinsically Disordered Proteins or Protein Regions Acting with Membranes in Autophagy
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DOI: 10.3390/membranes12050457
Abstract: Intrinsically disordered proteins and protein regions (IDPs/IDPRs) are mainly involved in signaling pathways, where fast regulation, temporal interactions, promiscuous interactions, and assemblies of structurally diverse components including membranes are essential. The autophagy pathway builds, de… read more here.
Keywords: theater self; intrinsically disordered; disordered proteins; protein regions ... See more keywords