The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)—preliminary molecular docking analysis
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DOI: 10.1007/s43440-021-00282-8
Abstract: Background The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified at the end of 2019. Despite growing understanding of SARS-CoV-2 in virology as well as many molecular studies, except remdesivir, no specific anti-SARS-CoV-2… read more here.
Keywords: protease; rna polymerase; proteins rna; ciprofloxacin levofloxacin ... See more keywords
Spatially Resolved Mapping of Endogenous Proteins and RNA in Living Cells
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DOI: 10.1016/j.bpj.2016.11.063
Abstract: I will describe our efforts to build molecular tools for studying mitochondria and the synapse in living cells and tissue. These might include tools for proteomic mapping, transcriptomic mapping, and/or neural circuit mapping. read more here.
Keywords: resolved mapping; endogenous proteins; proteins rna; living cells ... See more keywords
Multiplex digital spatial profiling of proteins and RNA in fixed tissue
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DOI: 10.1038/s41587-020-0472-9
Abstract: Digital Spatial Profiling (DSP) is a method for highly multiplex spatial profiling of proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The approach relies on (1) multiplexed readout of proteins or RNAs… read more here.
Keywords: digital spatial; proteins rna; rna fixed; profiling proteins ... See more keywords