Repressing expression of difficult-to-express recombinant proteins during the selection process increases productivity of CHO stable pools.
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DOI: 10.1002/bit.28435
Abstract: More than half of licensed therapeutic recombinant proteins (r-proteins) are manufactured using constitutively-expressing, stably-transfected Chinese hamster ovary (CHO) clones. While constitutive CHO expression systems have proven their efficacy for the manufacturing of monoclonal antibodies, many… read more here.
Keywords: stable pools; recombinant proteins; expression; proteins selection ... See more keywords