Custom DNA microarrays reveal diverse binding preferences of proteins and small molecules to thousands of G-quadruplexes.
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DOI: 10.1021/acschembio.9b00934
Abstract: Single-stranded DNA (ssDNA) containing four guanine repeats can form G-quadruplex (G4) structures. While cellular proteins and small molecules can bind G4s, it has been difficult to broadly assess their DNA binding specificity. Here, we use… read more here.
Keywords: dna microarrays; custom dna; dna; small molecules ... See more keywords