Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-98788-0_13
Abstract: Aldose reductase (AR) is an NADPH-dependent aldo-keto reductase that has been shown to be involved in the pathogenesis of several blinding diseases such as uveitis, diabetic retinopathy (DR) and cataract. However, possible mechanisms linking the… read more here.
Keywords: aldo keto; multifunctional proteins; keto reductases; therapeutic targets ... See more keywords
Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery.
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DOI: 10.1021/acs.jmedchem.9b01452
Abstract: Heterotrimeric G proteins are molecular switches in GPCR signaling pathways and regulate a plethora of physiological and pathological processes. GPCRs are efficient drug targets and more than 30% of the drugs in use target them.… read more here.
Keywords: targets drug; therapeutic targets; drug; heterotrimeric proteins ... See more keywords
MNK Proteins as Therapeutic Targets in Leukemia
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DOI: 10.2147/ott.s370874
Abstract: Abstract In leukemia, resistance to therapy is a major concern for survival. MAPK-interacting kinases (MNKs) have been identified as important activators of oncogenic-related signaling and may be mediators of resistance. Recent studies in leukemia models,… read more here.
Keywords: proteins therapeutic; mnk proteins; mnk inhibitors; targets leukemia ... See more keywords
Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases
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DOI: 10.3390/ijms23105672
Abstract: Most of the major retinal degenerative diseases are associated with significant levels of oxidative stress. One of the major sources contributing to the overall level of stress is the reactive oxygen species (ROS) generated by… read more here.
Keywords: targets neurodegenerative; stress; proteins therapeutic; uncoupling proteins ... See more keywords