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Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-98788-0_13
Abstract: Aldose reductase (AR) is an NADPH-dependent aldo-keto reductase that has been shown to be involved in the pathogenesis of several blinding diseases such as uveitis, diabetic retinopathy (DR) and cataract. However, possible mechanisms linking the…
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Keywords:
aldo keto;
multifunctional proteins;
keto reductases;
therapeutic targets ... See more keywords
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Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01452
Abstract: Heterotrimeric G proteins are molecular switches in GPCR signaling pathways and regulate a plethora of physiological and pathological processes. GPCRs are efficient drug targets and more than 30% of the drugs in use target them.…
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Keywords:
targets drug;
therapeutic targets;
drug;
heterotrimeric proteins ... See more keywords
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Published in 2023 at "OncoTargets and Therapy"
DOI: 10.2147/ott.s370874
Abstract: Abstract In leukemia, resistance to therapy is a major concern for survival. MAPK-interacting kinases (MNKs) have been identified as important activators of oncogenic-related signaling and may be mediators of resistance. Recent studies in leukemia models,…
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Keywords:
proteins therapeutic;
mnk proteins;
mnk inhibitors;
targets leukemia ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105672
Abstract: Most of the major retinal degenerative diseases are associated with significant levels of oxidative stress. One of the major sources contributing to the overall level of stress is the reactive oxygen species (ROS) generated by…
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Keywords:
targets neurodegenerative;
stress;
proteins therapeutic;
uncoupling proteins ... See more keywords