TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins.
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DOI: 10.1080/15548627.2021.1956105
Abstract: Until recently, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy were considered to be two independent systems that target proteins for degradation by proteasomes or via lysosomes, respectively. Here, we report that TRIM44 (tripartite motif containing 44)… read more here.
Keywords: degradation; proteins trim44; sqstm1 p62; system ... See more keywords