Selective Comprehensive Online NanoLCxCZE-MS Platform for Top-Down Proteoform Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c03469
Abstract: Efficient separation is crucial for an in-depth analysis of proteoforms in complex samples. Two-dimensional (2D) separation platforms exhibit increased selectivity and peak capacity compared to their one-dimensional components. Here, we present for the first time… read more here.
Keywords: analysis; proteoform analysis; selective comprehensive; platform ... See more keywords
Linker H1 Histone Direct Top-Down Proteoform Analysis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.5c00618
Abstract: Linker H1 histones are highly susceptible to a variety of post-translational modifications (PTMs) that play a critical role in chromatin dynamics and gene expression. In the present work, trapped ion mobility spectrometry in tandem with… read more here.
Keywords: linker; linker histone; proteoform analysis; histone ... See more keywords
New Interface for Faster Proteoform Analysis: Immunoprecipitation Coupled with SampleStream-Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.1c00026
Abstract: Different proteoform products of the same gene can exhibit differing associations with health and disease, and their patterns of modifications may offer more precise markers of phenotypic differences between individuals. However, currently employed protein-biomarker discovery… read more here.
Keywords: proteoform analysis; proteoform; faster proteoform; mass spectrometry ... See more keywords