Defining the Sarcomeric Proteoform Landscape in Ischemic Cardiomyopathy by Top-Down Proteomics.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00729
Abstract: Ischemic cardiomyopathy (ICM) is a prominent form of heart failure, but the molecular mechanisms underlying ICM remain relatively understudied due to marked phenotypic heterogeneity. Alterations in post-translational modifications (PTMs) and isoform switches in sarcomeric proteins… read more here.
Keywords: icm; top proteomics; sarcomeric proteoform; proteoform landscape ... See more keywords
Mapping the Proteoform Landscape of Five Human Tissues
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Proteome Research"
DOI: 10.26434/chemrxiv-2022-svlqz
Abstract: A functional understanding of the human body requires structure–function studies of proteins at scale. The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of products with modulated… read more here.
Keywords: proteoform landscape; mapping proteoform; proteoform; landscape five ... See more keywords