Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
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DOI: 10.1016/j.cell.2019.08.052
Abstract: We performed the first proteogenomic characterization of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 patients. Integrated proteogenomic analyses revealed consistency and discordance among multi-omics, activation status… read more here.
Keywords: hepatocellular carcinoma; hbv related; integrated proteogenomic; hbv ... See more keywords
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
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DOI: 10.1016/j.cell.2020.06.013
Abstract: To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and… read more here.
Keywords: lung adenocarcinoma; characterization reveals; therapeutic vulnerabilities; proteogenomic characterization ... See more keywords
Proteogenomic characterization of pancreatic ductal adenocarcinoma
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DOI: 10.1016/j.cell.2021.08.023
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent… read more here.
Keywords: proteogenomic characterization; characterization pancreatic; pancreatic ductal; ductal adenocarcinoma ... See more keywords
Comparative proteogenomic characterization of glioblastoma
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DOI: 10.2217/cns-2019-0003
Abstract: Aim: Glioblastoma multiforme (GBM) carries a dismal prognosis. Integrated proteogenomic analysis was performed to understand GBM pathophysiology. Patients & methods: 17 patient samples were analyzed for driver mutations, oncogenes, major pathway alterations and molecular changes… read more here.
Keywords: egfr; characterization glioblastoma; glioblastoma; comparative proteogenomic ... See more keywords