Polyethylene Glycol Based Changes to β-Sheet Protein Conformational and Proteolytic Stability Depend on Conjugation Strategy and Location.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00281
Abstract: The development of chemical strategies for site-specific protein modification now enables researchers to attach polyethylene glycol (PEG) to a protein drug at one or more specific locations (i.e., protein PEGylation). However, aside from avoiding enzyme… read more here.
Keywords: proteolytic stability; polyethylene glycol; conjugation strategy; stability ... See more keywords
Synthesis and Studies of Bulky Cycloalkyl α,β-Dehydroamino Acids that Enhance Proteolytic Stability.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01962
Abstract: Three new bulky cycloalkyl α,β-dehydroamino acids (ΔAAs) have been designed and synthesized. Each residue enhances the rigidity of model peptides and their stability to proteolysis, with larger ring sizes exhibiting greater effects. Peptides containing bulky… read more here.
Keywords: cycloalkyl; bulky cycloalkyl; dehydroamino acids; proteolytic stability ... See more keywords
Recent advances in proteolytic stability for peptide, protein, and antibody drug discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on drug discovery"
DOI: 10.1080/17460441.2021.1942837
Abstract: Introduction: To discover and develop a peptide, protein, or antibody into a drug requires overcoming multiple challenges to obtain desired properties. Proteolytic stability is one of the challenges and deserves a focused investigation.Areas covered: This… read more here.
Keywords: stability; peptide protein; proteolytic stability; drug ... See more keywords