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   Articles with "proteolytic stability" as a keyword



All‐hydrocarbon stapling enables improvement of antimicrobial activity and proteolytic stability of peptide Figainin 2

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recommendations! Published in 2024 at "Journal of Peptide Science"

DOI: 10.1002/psc.3566

Abstract: Figainin 2 is a cationic, hydrophobic, α‐helical host‐defense peptide with 28 residues, which was isolated from the skin secretions of the Chaco tree frog. It shows potent inhibitory activity against both Gram‐negative and Gram‐positive pathogens… read more here.

Keywords: proteolytic stability; stability; hydrocarbon; peptide ... See more keywords

Polyethylene Glycol Based Changes to β-Sheet Protein Conformational and Proteolytic Stability Depend on Conjugation Strategy and Location.

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recommendations! Published in 2017 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.7b00281

Abstract: The development of chemical strategies for site-specific protein modification now enables researchers to attach polyethylene glycol (PEG) to a protein drug at one or more specific locations (i.e., protein PEGylation). However, aside from avoiding enzyme… read more here.

Keywords: proteolytic stability; polyethylene glycol; conjugation strategy; stability ... See more keywords

Synthesis and Studies of Bulky Cycloalkyl α,β-Dehydroamino Acids that Enhance Proteolytic Stability.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c01962

Abstract: Three new bulky cycloalkyl α,β-dehydroamino acids (ΔAAs) have been designed and synthesized. Each residue enhances the rigidity of model peptides and their stability to proteolysis, with larger ring sizes exhibiting greater effects. Peptides containing bulky… read more here.

Keywords: cycloalkyl; bulky cycloalkyl; dehydroamino acids; proteolytic stability ... See more keywords
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Recent advances in proteolytic stability for peptide, protein, and antibody drug discovery.

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recommendations! Published in 2021 at "Expert opinion on drug discovery"

DOI: 10.1080/17460441.2021.1942837

Abstract: Introduction: To discover and develop a peptide, protein, or antibody into a drug requires overcoming multiple challenges to obtain desired properties. Proteolytic stability is one of the challenges and deserves a focused investigation.Areas covered: This… read more here.

Keywords: stability; peptide protein; proteolytic stability; drug ... See more keywords