Bridging substrate intake kinetics and bacterial growth phenotypes with flux balance analysis incorporating proteome allocation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61174-0
Abstract: Empirical kinetic models such as the Monod equation have been widely applied to relate the cell growth with substrate availability. The Monod equation shares a similar form with the mechanistically-based Michaelis-Menten kinetics for enzymatic processes,… read more here.
Keywords: flux balance; growth phenotypes; balance analysis; proteome allocation ... See more keywords
Dynamic proteome allocation regulates the profile of interaction of auxotrophic bacterial consortia
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.212008
Abstract: Microbial ecosystems are composed of multiple species in constant metabolic exchange. A pervasive interaction in microbial communities is metabolic cross-feeding and occurs when the metabolic burden of producing costly metabolites is distributed between community members,… read more here.
Keywords: interaction; allocation regulates; proteome allocation; dynamic proteome ... See more keywords
Bacterial fitness landscapes stratify based on proteome allocation associated with discrete aero-types
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008596
Abstract: The fitness landscape is a concept commonly used to describe evolution towards optimal phenotypes. It can be reduced to mechanistic detail using genome-scale models (GEMs) from systems biology. We use recently developed GEMs of Metabolism… read more here.
Keywords: aero types; biology; fitness; fitness landscape ... See more keywords