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   Articles with "proteome wide" as a keyword



Proteome‐Wide Survey of Cysteine Oxidation by Using a Norbornene Probe

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recommendations! Published in 2019 at "ChemBioChem"

DOI: 10.1002/cbic.201900729

Abstract: Rapid detection of cysteine oxidation in living cells is critical in advancing our understanding of responses to reactive oxygen species (ROS) and oxidative stress. Accordingly, there is a need to develop chemical probes that facilitate… read more here.

Keywords: oxidation; cysteine; norbornene probe; cysteine oxidation ... See more keywords

Proteome-Wide Mendelian Randomisation Study of Adverse Perinatal Outcomes

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recommendations! Published in 2025 at "Behavior Genetics"

DOI: 10.1007/s10519-025-10233-1

Abstract: Despite significant advances in pre- and postnatal care over the last century, adverse pregnancy related events still occur frequently. We used Mendelian randomisation (MR) to investigate potential causal effects of the mother’s and fetal blood… read more here.

Keywords: potentially causal; proteome wide; causal increased; mendelian randomisation ... See more keywords

Amyloid β accelerates age-related proteome-wide protein insolubility

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recommendations! Published in 2024 at "GeroScience"

DOI: 10.1007/s11357-024-01169-1

Abstract: Loss of proteostasis is a highly conserved feature of aging across model organisms and results in the accumulation of insoluble protein aggregates. Protein insolubility is also a unifying feature of major age-related neurodegenerative diseases, including… read more here.

Keywords: protein insolubility; age; age related; proteome wide ... See more keywords

Proteome-Wide Modeling of Transmembrane Alpha-Helical Homodimers by TMDOCK

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1941

Abstract: A novel energy-based method, TMDOCK, has been developed for ab initio modeling of 3D structures of parallel homodimers in membranes. Instead of exploring the entire conformational space, the method employs a fast template-driven global energy… read more here.

Keywords: energy; dimerization; method; proteome wide ... See more keywords

R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation.

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recommendations! Published in 2019 at "Molecular cell"

DOI: 10.1016/j.molcel.2019.04.018

Abstract: The comprehensive but specific identification of RNA-binding proteins as well as the discovery of RNA-associated protein functions remain major challenges in RNA biology. Here we adapt the concept of RNA dependence, defining a protein as… read more here.

Keywords: identification rna; rna dependent; rna; dependent proteins ... See more keywords

Proteome-Wide Characterizations of N6-Methyl-Adenosine Triphosphate- and N6-Furfuryl-Adenosine Triphosphate-Binding Capabilities of Kinases.

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recommendations! Published in 2021 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.1c02565

Abstract: Kinases catalyze the transfer of the γ-phosphate group from adenosine triphosphate (ATP) to their protein and small-molecule substrates, and this phosphorylation is a crucial element of multiple cell signaling pathways. Herein, we employed isotope-coded ATP… read more here.

Keywords: atp; adenosine triphosphate; endogenous kinases; proteome wide ... See more keywords

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.

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recommendations! Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c04986

Abstract: The development of MS-cleavable cross-linking mass spectrometry (XL-MS) has enabled the effective capture and identification of endogenous protein-protein interactions (PPIs) and their residue contacts at the global scale without cell engineering. So far, only lysine-reactive… read more here.

Keywords: linking mass; chemistry; cross linking; ppi ... See more keywords

A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation.

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recommendations! Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b00397

Abstract: Mapping of weak and hence transient interactions between low-abundance interacting molecules is still a major challenge in systems biology and protein biochemistry. Therefore, additional system-wide acting tools are needed to determine protein interactomics. Most important… read more here.

Keywords: biochemistry; noncanonical amino; amino acid; proteome wide ... See more keywords
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Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale.

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recommendations! Published in 2018 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.8b00341

Abstract: Over the past decade, a suite of new mass-spectrometry-based proteomics methods has been developed that now enables the conformational properties of proteins and protein-ligand complexes to be studied in complex biological mixtures, from cell lysates… read more here.

Keywords: structural biology; analysis; wide structural; proteome wide ... See more keywords

'Differential visual proteomics': Enabling the proteome-wide comparison of protein structures of single-cells.

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recommendations! Published in 2019 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.9b00447

Abstract: Proteins are involved in all tasks of life, and their characterization is essential to understand the underlying mechanisms of biological processes. We present a method called 'differential visual proteomics' geared to study proteome-wide structural changes… read more here.

Keywords: visual proteomics; protein; differential visual; proteomics enabling ... See more keywords

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09107-y

Abstract: Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry to interrogate ATP-mediated regulation of protein thermal stability and protein solubility… read more here.

Keywords: atp; profiling reveals; proteome wide; solubility ... See more keywords