Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Communications"
DOI: 10.1002/cac2.12192
Abstract: Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma (HCC), but the relationship between ubiquitination and metastasis need to be studied more systematically. We analyzed the ubiquitinome of HCC in this study… read more here.
Keywords: hepatocellular carcinoma; proteomics reveals; integrative proteomics; reveals role ... See more keywords
Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha‐Tubulins in Human Cells
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200414
Abstract: Tubulin detyrosination-tyrosination cycle regulates the stability of microtubules. Thus far described on α-tubulins, the tyrosination level is maintained by a single tubulin-tyrosine ligase (TTL). However, the precise dynamics and tubulin isoforms which undergo (de)tyrosination in… read more here.
Keywords: tyrosine; tyrosination; reveals protein; chemical proteomics ... See more keywords
Environmental proteomics reveals taxonomic and functional changes in an enriched aquatic ecosystem.
Sign Up to like & getrecommendations! Published in 2017 at "Ecosphere"
DOI: 10.1002/ecs2.1954
Abstract: Aquatic ecosystem enrichment can lead to distinct and irreversible changes to undesirable states. Understanding changes in active microbial community function and composition following organic-matter loading in enriched ecosystems can help identify biomarkers of such state… read more here.
Keywords: enriched aquatic; proteomics reveals; changes enriched; environmental proteomics ... See more keywords
Functional proteomics reveals that Slr0237 is a SigE‐regulated glycogen debranching enzyme pivotal for glycogen breakdown
Sign Up to like & getrecommendations! Published in 2024 at "PROTEOMICS"
DOI: 10.1002/pmic.202300222
Abstract: The group 2 σ factor for RNA polymerase SigE plays important role in regulating central carbon metabolism in cyanobacteria. However, the regulation of SigE for these pathways at a proteome level remains unknown. Using a… read more here.
Keywords: glycogen; debranching enzyme; proteomics reveals; reveals slr0237 ... See more keywords
Quantitative Proteomics Reveals Docosahexaenoic Acid-Mediated Neuroprotective Effects in Lipopolysaccharide-Stimulated Microglial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.9b00792
Abstract: The high levels of docosahexaenoic acid (DHA) in cell membranes within the brain have led to a number of studies exploring its function. These studies have shown that DHA can reduce inflammatory responses in microglial… read more here.
Keywords: docosahexaenoic acid; proteomics reveals; acid mediated; reveals docosahexaenoic ... See more keywords
Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00122
Abstract: Anandamide or N-arachidonoylethanolamine (AEA) is a signaling lipid that modulates neurotransmitter release via activation of the type 1 cannabinoid receptor (CB1R) in the brain. Termination of anandamide signaling is thought to be mediated via a… read more here.
Keywords: wobe437; reveals targets; inhibitor; neuro cells ... See more keywords
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10819
Abstract: Phenotypic screening is a powerful approach to identify novel antibiotics, but elucidation of the targets responsible for the antimicrobial activity is often challenging in the case of compounds with a polypharmacological mode of action. Here,… read more here.
Keywords: reveals antibiotic; antibiotic targets; chemical proteomics; chemical ... See more keywords
Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-27398-y
Abstract: Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry-based proteomics in combination with subcellular fractionation can provide comprehensive maps… read more here.
Keywords: phospho signaling; spatial proteomics; reveals phospho; proteomics reveals ... See more keywords
Proteomics reveals that quinoa bioester promotes replenishing effects in epidermal tissue
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76325-6
Abstract: The continuous search for natural products that attenuate age-related losses has increasingly gained notice; among them, those applicable for skin care have drawn significant attention. The bioester generated from the Chenopodium quinoa’s oil is a… read more here.
Keywords: bioester; bioester promotes; quinoa bioester; proteomics reveals ... See more keywords
Proteomics Reveals Molecular Changes in Insomnia Patients with More Dreams
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/6181943
Abstract: Background Insomnia is a sleep disorder and the cause of many healthy problems. However, there are few studies on patients with insomnia and dreaminess at present. Therefore, this study is aimed at exploring the pathological… read more here.
Keywords: insomnia patients; ppi network; patients dreams; reveals molecular ... See more keywords
Abstract 1881: Bimodality in pan-cancer proteomics reveals new biomarker discovery opportunities
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1881
Abstract: Bimodal protein expression, characterized by a protein distribution with two modes, is linked to phenotypic variation across various biological systems. While previous studies focused on RNA expression data, we developed a bimodality model tailored for… read more here.
Keywords: cancer; proteomics reveals; bimodality pan; pan cancer ... See more keywords