Yeast chaperones and ubiquitin ligases contribute to proteostasis during arsenite stress by preventing or clearing protein aggregates.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14638
Abstract: Arsenite causes proteotoxicity by targeting nascent proteins for misfolding and aggregation. Here, we assessed how selected yeast chaperones and ubiquitin ligases contribute to proteostasis during arsenite stress. Loss of the ribosome-associated chaperones Zuo1, Ssz1, and… read more here.
Keywords: proteostasis arsenite; yeast chaperones; arsenite stress; ubiquitin ligases ... See more keywords
Targeting mitochondrial function and proteostasis to mitigate dynapenia
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Applied Physiology"
DOI: 10.1007/s00421-017-3730-x
Abstract: Traditionally, interventions to treat skeletal muscle aging have largely targeted sarcopenia—the age-related loss of skeletal muscle mass. Dynapenia refers to the age-related loss in skeletal muscle function due to factors outside of muscle mass, which… read more here.
Keywords: skeletal muscle; muscle; mitochondrial function; proteostasis ... See more keywords
Cellular Proteostasis in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1334-z
Abstract: The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated through a vast network of biochemical pathways. This requires the regulated control of protein folding, post-translational modification, and protein degradation. Due to the… read more here.
Keywords: protein; cellular proteostasis; proteostasis; neurodegenerative diseases ... See more keywords
The RAB GTPase RAB18 modulates macroautophagy and proteostasis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.112
Abstract: Macroautophagy is a conserved degradative pathway and its deterioration is linked to disturbances in cellular proteostasis and multiple diseases. Here, we show that the RAB GTPase RAB18 modulates autophagy in primary human fibroblasts. The knockdown… read more here.
Keywords: rab gtpase; proteostasis; rab18; rab18 modulates ... See more keywords
The linear ubiquitin E3 ligase-Relish pathway is involved in the regulation of proteostasis in Drosophila muscle during aging.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.135
Abstract: Linear ubiquitination is an atypic ubiquitination process that directly connects the N- and C-termini of ubiquitin and is catalyzed by HOIL-1-interacting protein (HOIP). It is involved in the immune response or apoptosis by activating the… read more here.
Keywords: lubel; muscle; ubiquitin ligase; linear ubiquitin ... See more keywords
Impact of high hydrostatic pressure on bacterial proteostasis.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2017.03.005
Abstract: High hydrostatic pressure (HHP) is an important factor that limits microbial growth in deep-sea ecosystems to specifically adapted piezophiles. Furthermore, HHP treatment is used as a novel food preservation technique because of its ability to… read more here.
Keywords: hhp; proteostasis; impact high; high hydrostatic ... See more keywords
HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.09.001
Abstract: Age-dependent ectopic fat accumulation (EFA) in animals contributes to the progression of tissue aging and diseases such as obesity, diabetes, and cancer. However, the primary causes of age-dependent EFA remain largely elusive. Here, we characterize… read more here.
Keywords: age dependent; age; proteostasis; plin2 ... See more keywords
Secretory proteostasis of the retinal pigmented epithelium: Impairment links to age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2020.100859
Abstract: Secretory proteostasis integrates protein synthesis, processing, folding and trafficking pathways that are essential for efficient cellular secretion. For the retinal pigment epithelium (RPE), secretory proteostasis is of vital importance for the maintenance of the structural… read more here.
Keywords: macular degeneration; secretory proteostasis; age related; related macular ... See more keywords
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.01.006
Abstract: Neurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of proteostasis. Proteostasis refers to all the processes by which cells control the abundance and… read more here.
Keywords: factor nrf2; proteostasis; neurodegenerative diseases; modulation proteostasis ... See more keywords
Mechanisms Linking Mitochondrial Dysfunction and Proteostasis Failure.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.01.008
Abstract: Maintaining cellular protein homeostasis (proteostasis) is an essential task for all eukaryotes. Proteostasis failure worsens with aging and is considered a cause of and a therapeutic target for age-related diseases including neurodegenerative disorders. The cellular… read more here.
Keywords: mechanisms linking; mitochondrial dysfunction; proteostasis; proteostasis failure ... See more keywords
The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2019.12.002
Abstract: Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated… read more here.
Keywords: crossroad proteostasis; proteostasis; sigma receptor; receptor crossroad ... See more keywords