Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner
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DOI: 10.1080/15548627.2024.2389607
Abstract: ABSTRACT Aging is often accompanied by a decline in proteostasis, manifested as an increased propensity for misfolded protein aggregates, which are prevented by protein quality control systems, such as the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy.… read more here.
Keywords: pharmacological inhibition; associated aging; proteostasis associated; inhibition usp14 ... See more keywords