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   Articles with "proteostasis network" as a keyword



Emerging potential of cannabidiol in reversing proteinopathies

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recommendations! Published in 2021 at "Ageing Research Reviews"

DOI: 10.1016/j.arr.2020.101209

Abstract: The aberrant accumulation of disease-specific protein aggregates accompanying cognitive decline is a pathological hallmark of age-associated neurological disorders, also termed as proteinopathies, including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and multiple sclerosis.… read more here.

Keywords: emerging potential; proteostasis network; cannabidiol; disease ... See more keywords

A proteostasis network safeguards the chloroplast proteome

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recommendations! Published in 2022 at "Essays in Biochemistry"

DOI: 10.1042/ebc20210058

Abstract: Abstract Several protein homeostasis (proteostasis) pathways safeguard the integrity of thousands of proteins that localize in plant chloroplasts, the indispensable organelles that perform photosynthesis, produce metabolites, and sense environmental stimuli. In this review, we discuss… read more here.

Keywords: chloroplast proteome; network safeguards; proteostasis network; proteostasis ... See more keywords

Proteostasis disturbance in amyotrophic lateral sclerosis

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recommendations! Published in 2017 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddx274

Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motoneurons in the brain and spinal cord leading to paralysis and death. Although the etiology of ALS remains poorly understood, abnormal protein aggregation and altered… read more here.

Keywords: proteostasis disturbance; proteostasis; amyotrophic lateral; proteostasis network ... See more keywords
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Functional Modules of the Proteostasis Network.

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recommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"

DOI: 10.1101/cshperspect.a033951

Abstract: Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis) and prevent the accumulation of potentially toxic protein aggregates. This proteostasis network (PN) comprises the machineries for the biogenesis, folding, conformational maintenance,… read more here.

Keywords: network; functional modules; proteostasis; proteostasis network ... See more keywords

Dynamic Changes in Proteostasis Network Activity Influence Hematopoietic Stem Cell Ontogeny and Human Umbilical Cord Blood Fitness

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-203968

Abstract: Hematopoietic stem cells (HSCs) establish hematopoiesis and maintain regeneration of blood and immune cells to meet shifting demands for blood cell production during development and throughout life. The protein homeostasis (proteostasis) network is uniquely configured… read more here.

Keywords: proteostasis network; stem; proteostasis; protein ... See more keywords

The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope

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recommendations! Published in 2022 at "PLoS Biology"

DOI: 10.1371/journal.pbio.3001569

Abstract: The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex folding landscapes. It is also possible, at least in theory, for proteostasis mechanisms that… read more here.

Keywords: proteostasis; proteostasis network; sequence space; space accessible ... See more keywords

Determining the effects of nanoparticulate air pollution on proteostasis in Caenorhabditis elegans

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recommendations! Published in 2020 at "PLoS ONE"

DOI: 10.1371/journal.pone.0243419

Abstract: The proteostasis network comprises the biochemical pathways that together maintain and regulate proper protein synthesis, transport, folding, and degradation. Many neurodegenerative diseases are characterized by a failure of the proteostasis network to sustain the health… read more here.

Keywords: air pollution; proteostasis; proteostasis network;

Nanoparticulate air pollution disrupts proteostasis in Caenorhabditis elegans

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recommendations! Published in 2023 at "PLOS ONE"

DOI: 10.1371/journal.pone.0275137

Abstract: The proteostasis network comprises the biochemical pathways that together maintain and regulate proper protein synthesis, transport, folding, and degradation. Many progressive neurodegenerative diseases, such as Huntington’s disease (HD) and Alzheimer’s disease (AD), are characterized by… read more here.

Keywords: proteostasis; air pollution; proteostasis network; protein ... See more keywords