Novel organo-osmium(ii) proteosynthesis inhibitors active against human ovarian cancer cells reduce gonad tumor growth inCaenorhabditis elegans
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DOI: 10.1039/c9qi01704f
Abstract: This work reports the synthesis and characterization of some novel osmium(II) complexes with potential as anticancer drugs tested in vitro and in vivo. The complexes have a structure [(η6-p-cym)Os(C^N)(X)]0/+, where the C^N ligand is deprotonated… read more here.
Keywords: tumor growth; proteosynthesis; ovarian cancer; cancer cells ... See more keywords
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments
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DOI: 10.26508/lsa.202201560
Abstract: This study clarifies the long-standing misuse of emetine as a lagging strand synthesis-specific inhibitor. Emetine blocks the synthesis of both DNA strands by the inhibition of protein biosynthesis. DNA synthesis of the leading and lagging… read more here.
Keywords: emetine; inhibition; replication; proteosynthesis ... See more keywords