Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.121
Abstract: The sole nonredundant role of the thymic medulla is to induce central tolerance, a vital process that depends on promiscuous gene expression (pGE), a unique feature of medullary thymic epithelial cells (mTECs). Although pGE enhances… read more here.
Keywords: homeostasis; epithelial cells; mtecs; proteotoxic stress ... See more keywords
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.392
Abstract: Chromatin DNA damage response (DDR) is orchestrated by the E3 ubiquitin ligase ring finger protein 168 (RNF168), resulting in ubiquitin-dependent recruitment of DDR factors and tumor suppressors breast cancer 1 (BRCA1) and p53 binding protein… read more here.
Keywords: rnf168; proteotoxic stress; cancer; instability ... See more keywords
Mitochondrial metabolism promotes adaptation to proteotoxic stress
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0291-9
Abstract: The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but are key to understanding how tumor cells, particularly in vivo, are largely resistant to proteasome inhibitors. Analysis of cancer cell lines, mouse… read more here.
Keywords: proteasome inhibitor; stress; proteotoxic stress; mitochondrial metabolism ... See more keywords
The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.13.480280
Abstract: When cells encounter stressful situations, they activate the integrated stress response (ISR), which limits total protein synthesis and redirects translation to proteins that help the cells to cope. The ISR has also been implicated in… read more here.
Keywords: proteotoxic stress; stress; scc stem; stress response ... See more keywords
Enhancing Proteotoxic Stress in Leiomyosarcoma Cells Triggers Mitochondrial Dysfunctions, Cell Death, and Antitumor Activity in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0521
Abstract: Leiomyosarcomas are rare and aggressive tumors characterized by a complex karyotype. Surgical resection with or without radiotherapy and chemotherapy is the standard curative treatment. Unfortunately, a high percentage of leiomyosarcomas recurs and metastasizes. In these… read more here.
Keywords: cell death; proteotoxic stress; cells triggers; leiomyosarcoma cells ... See more keywords
Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0202758
Abstract: Response of tumours to Hsp90 inhibitors is highly variable and their clinical effects are unpredictable, emphasising the need for a predictive marker. We postulated that sensitivity to Hsp90 inhibitors is connected to basal proteotoxic stress… read more here.
Keywords: sensitivity; hsp90 inhibition; proteotoxic stress; hsf1 ... See more keywords
Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201911861
Abstract: The ubiquitin–proteasome system degrades ubiquitin‐modified proteins to maintain protein homeostasis and to control signalling. Whole‐genome sequencing of patients with severe deafness and early‐onset cataracts as part of a neurological, sensorial and cutaneous novel syndrome identified… read more here.
Keywords: proteasome subunit; proteotoxic stress; psmc3;
Profiling the Hsp70 Chaperone Network in Heat-Induced Proteotoxic Stress Models of Human Neurons
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12030416
Abstract: Simple Summary Rising temperatures and consequent heat waves are detrimental manifestations of climate change for the population’s health. Exposure to extreme environmental heat during episodes of intense and long-lasting heat waves is a direct cause… read more here.
Keywords: proteotoxic stress; damage; brain; heat induced ... See more keywords
An Integrated Approach Reveals DNA Damage and Proteotoxic Stress as Main Effects of Proton Radiation in S. cerevisiae
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105493
Abstract: Proton radiotherapy (PRT) has the potential to reduce the normal tissue toxicity associated with conventional photon-based radiotherapy (X-ray therapy, XRT) because the active dose can be more directly targeted to a tumor. Although this dosimetric… read more here.
Keywords: proteotoxic stress; stress; dna damage; xrt ... See more keywords