Environment-transformable sequence–structure relationship: a general mechanism for proteotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0369-0
Abstract: In his Nobel Lecture, Anfinsen stated “the native conformation is determined by the totality of interatomic interactions and hence by the amino acid sequence, in a given environment.” As aqueous solutions and membrane systems co-exist… read more here.
Keywords: environment transformable; transformable sequence; membrane; proteotoxicity ... See more keywords
Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.02.003
Abstract: Proteasome inhibitors have been shown to induce cell death in cancer cells by triggering an acute proteotoxic stress response characterized by accumulation of poly-ubiquitinated proteins, ER stress and the production of reactive oxygen species. The… read more here.
Keywords: proteasome inhibitor; inhibitor; ap15; proteotoxicity ... See more keywords
USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L–SMAD pathway
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2014349117
Abstract: Significance Protein homeostasis is fundamental to the functioning of all living cells. Perturbation of the homeostasis, or proteotoxicity, plays an important role in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative diseases. To guard… read more here.
Keywords: protein; quality control; pathway; proteotoxicity ... See more keywords
HSP27-HSP40-HSP70-HSP90 pathway participated in molecular mechanism of selenium alleviating lead-caused oxidative damage and proteotoxicity in chicken Bursa of Fabricius.
Sign Up to like & getrecommendations! Published in 2022 at "Animal biotechnology"
DOI: 10.1080/10495398.2022.2155175
Abstract: Lead (Pb), a toxic environmental pollutant, is hazardous to the health of humans and birds. Bursa of Fabricius (BF) is a unique organ of birds. Toxic substances can attack BF and induce proteotoxicity. Increased heat… read more here.
Keywords: oxidative damage; hsp27 hsp40; proteotoxicity; damage ... See more keywords