Identification and characterization of a factor Va-binding site on human prothrombin fragment 2
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38857-4
Abstract: The fragment 2 domain (F2) of prothrombin and its interaction with factor (F) Va is known to contribute significantly to prothrombinase-catalyzed activation of prothrombin. The extent to which the F2-FVa interaction affects the overall thrombin… read more here.
Keywords: prothrombin; fva; thrombin generation; fragment ... See more keywords
Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40435-7
Abstract: Haemostasis is governed by a highly complex system of interacting proteins. Due to the central role of thrombin, thrombin generation and specifically the thrombin generation curve (TGC) is commonly used as an indicator of haemostatic… read more here.
Keywords: system; prothrombin; age; haemostatic activity ... See more keywords
Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49552-9
Abstract: Prothrombin complex concentrates (PCC) are fractionated plasma protein drugs that reverse warfarin anticoagulation. PCC may control more general bleeding. We sought to identify the dominant procoagulant factor in PCC in vivo. We tested PCC or… read more here.
Keywords: prothrombin; pcc; aso fii; complex concentrates ... See more keywords
Recombinant Factor VIIa–Mediated Activation of Prothrombin Complex Concentrates
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/1076029616663848
Abstract: Recombinant factor VIIa (rFVIIa) is used in the management of bleeding in patients with hemophilia. A generic biosimilar version of NovoSeven is also developed (AryoSeven). To compare the activation profile of NovoSeven and AryoSeven, 2… read more here.
Keywords: factor viia; recombinant factor; prothrombin; activation ... See more keywords
Prothrombin R541W Mutation Impairs Protein C Activation and Constitutes a New Genetic Risk Factor for Venous Thrombosis
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-127694
Abstract: Defective protein C (PC) pathway predisposes patients to venous thromboembolism (VTE)and is mostly, but not exclusively, attributed tohereditary PC or protein S (PS) deficiencies and activated PC resistance caused by factor V Leiden mutation. In… read more here.
Keywords: medicine; venous thrombosis; constitutes new; prothrombin ... See more keywords
In Hemophilia Α Plasma Treated with Emicizumab, Factor IXa in Activated Prothrombin Complex Concentrates Is the Dominant Contributor to Enhanced Thrombin Generation
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-139586
Abstract: Background. Recently a novel bifunctional antibody (emicizumab) that binds both factor IXa and factor X has been used to treat hemophilia A. Emicizumab has proven remarkably effective as a prophylactic treatment for hemophilia A; however… read more here.
Keywords: hemophilia plasma; prothrombin; generation; thrombin generation ... See more keywords
Cryo-EM structure of the prothrombin-prothrombinase complex.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022015807
Abstract: The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa (fXa), the cofactor fVa, Ca2+ and phospholipids, activates the zymogen prothrombin to… read more here.
Keywords: prothrombinase complex; prothrombin; cryo structure;
Prothrombin time is predictive of low plasma prothrombin concentration and clinical outcome in patients with trauma hemorrhage: analyses of prospective observational cohort studies
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine"
DOI: 10.1186/s13049-016-0332-2
Abstract: BackgroundFibrinogen and prothrombin have been suggested to become rate limiting in trauma associated coagulopathy. Administration of fibrinogen is now recommended, however, the importance of prothrombin to patient outcome is unknown.MethodsWe have utilized two trauma patient… read more here.
Keywords: prothrombin; database; clinical outcome; prothrombin concentration ... See more keywords
Three Cases of Unprovoked Venous Thromboembolism with Prothrombin p.Arg596Gln Variant and a Literature Review of Antithrombin Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine"
DOI: 10.2169/internalmedicine.9718-22
Abstract: Antithrombin resistance (ATR) is a newly identified strong genetic predisposition to venous thromboembolism (VTE) caused by genetic variations in prothrombin with substitutions of Arg at position 596 with either Leu, Gln, or Trp. In the… read more here.
Keywords: prothrombin; arg596gln; antithrombin resistance; venous thromboembolism ... See more keywords