Vitamin K Antagonist Reversal for Urgent Surgery Using 4-Factor Prothrombin Complex Concentrates
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DOI: 10.1001/jamanetworkopen.2024.24758
Abstract: This randomized clinical trial assesses the hemostatic efficacy of an investigational 4-factor prothrombin complex concentrate in adults before undergoing urgent surgery with substantial bleeding risk. read more here.
Keywords: factor prothrombin; prothrombin complex; urgent surgery;
Initiation of a fixed- dose four- factor prothrombin complex concentrate protocol
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-02020-7
Abstract: We read with much interest the article “Initiation of a fixeddose fourfactor prothrombin complex concentrate protocol” published by Fuh. L et al. in your esteemed journal. In this study, authors have included 63 patients with… read more here.
Keywords: administration; inr; administration pcc; prothrombin complex ... See more keywords
Efficacy of 4-Factor Prothrombin Complex Concentrates in Factor Xa Inhibitor-Associated Intracranial Bleeding
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DOI: 10.1007/s12028-020-00968-6
Abstract: Background/Objective Intracranial bleeding (ICB) is a feared complication of systemic anticoagulation. Factor Xa inhibitors (FXaI) are used frequently due to their improved safety profile and predictable kinetics. Andexanet alfa was recently approved for emergent reversal… read more here.
Keywords: efficacy; intracranial bleeding; complex concentrates; prothrombin complex ... See more keywords
Activated prothrombin complex concentrates for direct oral anticoagulant-associated bleeding or urgent surgery: Hemostatic and thrombotic outcomes.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis research"
DOI: 10.1016/j.thromres.2020.06.044
Abstract: INTRODUCTION Studies evaluating the use of activated prothrombin complex concentrates (aPCCs) for DOAC-associated bleeding are sparse. MATERIALS AND METHODS We conducted a retrospective study of patients receiving aPCC for DOAC-associated bleeding or for pre-operative optimization… read more here.
Keywords: urgent surgery; apcc; activated prothrombin; prothrombin complex ... See more keywords
COLLABORATIVE PRESCRIBING OF FOUR-FACTOR PROTHROMBIN COMPLEX CONCENTRATE FOR EMERGENT ANTICOAGULATION REVERSAL
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DOI: 10.1016/s0735-1097(19)32742-1
Abstract: Emergent reversal of oral anticoagulation (OAC), including vitamin K antagonist (VKA) and direct-acting oral anticoagulant (DOAC) therapy, continues to be an important aspect of OAC due to the potential for serious bleeding events. Four-factor prothrombin… read more here.
Keywords: reversal; complex concentrate; emergent; factor prothrombin ... See more keywords
3-Factor versus 4-Factor Prothrombin Complex Concentrates for the Reversal of Vitamin K Antagonist-Associated Coagulopathy: A Systematic Review and Meta-analysis
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DOI: 10.1055/s-0042-1758653
Abstract: Long-term anticoagulation is used worldwide to prevent or treat thrombotic events. Anticoagulant therapy using vitamin K antagonists (VKAs) is well established; however, anticoagulants carry an increased risk of potentially life-threatening bleeding. In cases of bleeding… read more here.
Keywords: associated coagulopathy; meta analysis; complex concentrates; factor ... See more keywords
Real-life experiences with goal-directed prohemostatic therapy with fibrinogen concentrate, prothrombin complex concentrate, and recombinant factor VIIa: a retrospective study of 287 consecutive patients
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2040048
Abstract: Abstract The Danish Capital Region Blood Bank operates a 24/7 on-call service staffed with physicians specialized in hemostatic management to guide clinicians in hemostatic resuscitation, including administration of prohemostatic therapy (PHT). The outcome of patients… read more here.
Keywords: complex concentrate; fibrinogen concentrate; concentrate; recombinant factor ... See more keywords
Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate
Sign Up to like & getrecommendations! Published in 2018 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2018.1440858
Abstract: ABSTRACT The relative clinical efficacy of 4-factor prothrombin complex concentrate (4F-PCC) in oral anticoagulant–associated intracranial hemorrhage is unknown, especially for factor Xa–inhibiting anticoagulants. We report short-term outcomes of patients with oral anticoagulant–associated intracranial hemorrhage on… read more here.
Keywords: intracranial hemorrhage; hemorrhage; prothrombin complex; factor ... See more keywords
551: SINGLE-INSTITUTION COMPARISON OF 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE VERSUS FRESH FROZEN PLASMA
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DOI: 10.1097/01.ccm.0000528568.22798.ca
Abstract: www.ccmjournal.org Critical Care Medicine • Volume 46 • Number 1 (Supplement) Learning Objectives: Randomized controlled trials have found four-factor prothrombin complex concentrate (4F-PCC) to be as effective as fresh frozen plasma (FFP) for acute reversal… read more here.
Keywords: medicine; fresh frozen; versus; prothrombin complex ... See more keywords
564: CHARACTERIZING THE USE OF 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000528580.60916.80
Abstract: www.ccmjournal.org Critical Care Medicine • Volume 46 • Number 1 (Supplement) Learning Objectives: Off-label medication use is common in critically ill patients in the United States. Kcentra® is a 4-factor prothrombin complex concentrate (4PCC) approved… read more here.
Keywords: medicine; use; prothrombin complex; factor prothrombin ... See more keywords
476: EVALUATION OF FOUR-FACTOR PROTHROMBIN COMPLEX CONCENTRATE UTILIZATION AT A 591-BED TEACHING HOSPITAL
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DOI: 10.1097/01.ccm.0000551228.12511.91
Abstract: Learning Objectives: Four Factor Prothrombin Complex Concentrate (4F-PCC) is indicated for urgent reversal of vitamin K antagonist in patients with acute major bleeding or in need of urgent surgery/invasive procedure. Vitamin K is administered concurrently… read more here.
Keywords: administration; pcc; four factor; prothrombin complex ... See more keywords