A discrepancy between prothrombin time and Normotest (Hepaplastintest) results is useful for diagnosis of acquired factor V inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Hematology"
DOI: 10.1007/s12185-018-2453-z
Abstract: Acquired coagulation factor inhibitors are rare. Among them, coagulation factor V (FV) inhibitor is particularly uncommon and presents with variable clinical manifestations. Certain acquired FV inhibitor patients have only mild bleeding or, in select cases,… read more here.
Keywords: factor inhibitors; diagnosis; time; normotest hepaplastintest ... See more keywords
Prolonged prothrombin time as an early prognostic indicator of severe acute respiratory distress syndrome in patients with COVID-19 related pneumonia
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DOI: 10.1080/03007995.2020.1853510
Abstract: Abstract Background Clinical observations demonstrated that COVID-19 related pneumonia is often accompanied by hematological and coagulation abnormalities including lymphopenia, thrombocytopenia, and prolonged prothrombin time. The evaluation of laboratory findings including coagulation and inflammation parameters may… read more here.
Keywords: covid patients; covid related; admission; covid ... See more keywords
A novel prothrombin time method to measure all non-vitamin K-dependent oral anticoagulants (NOACs)
Sign Up to like & getrecommendations! Published in 2017 at "Upsala Journal of Medical Sciences"
DOI: 10.1080/03009734.2017.1370040
Abstract: Abstract Background: There is a clinical need for point-of-care (POC) methods for non-vitamin K-dependent oral anticoagulants (NOACs). We modified a routine POC procedure: Zafena’s Simple Simon™ PT-INR, a room-temperature, wet-chemistry prothrombin time method of the… read more here.
Keywords: non vitamin; dependent oral; chemistry; prothrombin time ... See more keywords
Associations among Plasma Concentrations of Edoxaban and M-4, Prothrombin Time, and the SLCO1B1*15 Haplotype in Patients With Nonvalvular Atrial Fibrillation
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001042
Abstract: Supplemental Digital Content is Available in the Text. Introduction: The authors aimed to examine the impact of single nucleotide polymorphisms in P-glycoprotein, the hepatic uptake transporter organic anion transporter protein 1B1, cytochrome P450 (CYP) 3A5,… read more here.
Keywords: patients nonvalvular; concentrations edoxaban; slco1b1 haplotype; prothrombin time ... See more keywords
Early‐phase prothrombin time‐international normalized ratio in acute liver injury indicates the timing of therapeutic intervention and predicts prognostic improvement
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology Research"
DOI: 10.1111/hepr.13848
Abstract: We investigated whether an early‐phase prothrombin time‐international normalized ratio (PT‐INR) is an interventional prognostic indicator for patients with acute liver injury, including acute liver failure. read more here.
Keywords: acute liver; early phase; phase prothrombin; international normalized ... See more keywords
A performance evaluation of a novel human recombinant tissue factor prothrombin time reagent (Revohem™ PT)
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.12691
Abstract: A new prothrombin time reagent (Revohem™ PT) based on recombinant human tissue factor produced by the silkworm‐baculovirus expression system was tested. The aim of this study was to compare the performance of the new PT… read more here.
Keywords: tissue factor; time reagent; reagent revohem; prothrombin time ... See more keywords
Effect of the reaction temperature on the prothrombin time and the apparent International Normalized Ratio determined with International Standards for thromboplastins.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.13737
Abstract: INTRODUCTION The definition of the International Normalized Ratio (INR) depends on a reference measurement procedure for the prothrombin time (PT) determined with international standards for thromboplastins. The agreed water bath temperature for PT determination in… read more here.
Keywords: temperature; international standards; standards thromboplastins; reaction temperature ... See more keywords
Evaluation of newly‐developed modified diluted prothrombin time reagent in non‐valvular atrial fibrillation patients with direct oral anticoagulants: A comparative study with conventional reagents
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13971
Abstract: A single assay to assess the effect of the direct FXa inhibitor is needed clinically because prothrombin (PT) assay is not yet sensitive enough for accurate evaluation. We developed modified diluted prothrombin time (mdPT) assay… read more here.
Keywords: developed modified; time; time reagent; modified diluted ... See more keywords
Therapeutic monitoring of rivaroxaban in dogs using thromboelastography and prothrombin time
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DOI: 10.1111/jvim.15478
Abstract: Abstract Background The chromogenic anti‐Xa assay, the gold standard for monitoring the anti‐Xa effect of rivaroxaban, is not available as a cage‐side diagnostic test for use in a clinical setting. Hypothesis/Objectives To evaluate clinical modalities… read more here.
Keywords: point care; time; monitoring; monitoring rivaroxaban ... See more keywords
Clinical bleeding and thrombin generation in admissions to critical care with prolonged prothrombin time: an exploratory study
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DOI: 10.1111/trf.14605
Abstract: Prolongation of prothrombin time (PT) is often recorded in critical illness, but has limited ability to predict risk of bleeding. This exploratory study was aimed at assessing a role for thrombin generation (TG) to predict… read more here.
Keywords: exploratory study; thrombin generation; prothrombin time;
Polymethyl Methacrylate-Based Smart Microfluidic Point-of-Care Testing of Prothrombin Time and International Normalized Ratio through Optical Detection
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/5975228
Abstract: The mechanical heart valve is a crucial solution for many patients. However, it cannot function on the state of blood as human tissue valves. Thus, people with mechanical valves are put under anticoagulant therapy. A… read more here.
Keywords: time; prothrombin time; normalized ratio; international normalized ... See more keywords