Cryo-EM structure of the prothrombin-prothrombinase complex.
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DOI: 10.1182/blood.2022015807
Abstract: The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa (fXa), the cofactor fVa, Ca2+ and phospholipids, activates the zymogen prothrombin to… read more here.
Keywords: prothrombinase complex; prothrombin; cryo structure;