Distribution of RET proto‐oncogene variants in children with appendicitis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1864
Abstract: In addition to patient‐related systemic factors directing the immune response, the pathomechanisms of appendicitis (AP) might also include insufficient drainage leading to inflammation caused by decreased peristalsis. Genetic predisposition accounts for 30%–50% of AP. M.… read more here.
Keywords: oncogene variants; distribution ret; proto oncogene; ret proto ... See more keywords
Fishing wild-type sparing inhibitors of proto-oncogene c-met variants in renal cell carcinoma from a curated tyrosine kinase inhibitor pool using analog-sensitive kinase technology.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.07.005
Abstract: A variety of missense mutations in proto-oncogene protein tyrosine kinase c-Met have been clinically observed in the patients and families of papillary renal cell carcinoma (pRCC), imparting that the kinase mutations can be exploited as… read more here.
Keywords: renal cell; inhibitor; kinase; proto oncogene ... See more keywords
Novel RET Proto-oncogene Variants Identified in Turkish Patients with Thyroid Carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144611
Abstract: Thyroid cancer is one of the few malignancies whose incidence is increasing in the last decades. Advances in understanding the molecular mechanisms lead to provide opportunity for prevention, effective early identification and targeted therapies for… read more here.
Keywords: proto oncogene; variants identified; oncogene variants; ret proto ... See more keywords
Proto-oncogene serine/threonine kinase PIM3 promotes cell migration via modulating Rho GTPase signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00821
Abstract: The proto-oncogene serine/threonine-protein kinase PIM3 plays critical roles in cancer, and it has been extensively exploited as a drug target. Here we investigated the quantitative changes in the cellular proteome and phosphoproteome in liver cancer… read more here.
Keywords: pim3; cell migration; proto oncogene; rho gtpase ... See more keywords
Downsizing Proto-oncogene cFos to Short Helix-Constrained Peptides That Bind Jun.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00303
Abstract: The oncogenic transcription factor activator protein-1 (AP-1) is a DNA-binding protein that assembles through dimerization of Fos and Jun protein subunits, their leucine-rich helical sequences entwining into a coiled-coil structure. This study reports on downsizing… read more here.
Keywords: downsizing proto; jun; proto oncogene; cfos ... See more keywords
Hinge like domain motion facilitates human RBMS1 protein binding to proto-oncogene c-myc promoter
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab363
Abstract: Abstract DNA binding proteins recognize DNA specifically or non-specifically using direct and indirect readout mechanisms like sliding, hopping, and diffusion. However, a common difficulty in explicitly elucidating any particular mechanism of site-specific DNA-protein recognition is… read more here.
Keywords: protein; proto oncogene; rbms1 protein; human rbms1 ... See more keywords
High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.276028.121
Abstract: Genomic rearrangements are known to result in proto-oncogene deregulation in many cancers, but the link to genome 3D structure remains poorly understood. Here we used the highly-predictive heteromorphic polymer (HiP-HoP) model to predict chromatin conformations… read more here.
Keywords: ccnd1; proto oncogene; genomic rearrangements; oncogene deregulation ... See more keywords
ProtoPred: Advancing Oncological Research Through Identification of Proto-Oncogene Proteins
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Access"
DOI: 10.1109/access.2021.3076448
Abstract: Proto-oncogenes are the genes that have the potential to transform normal cells into cancer cells as a result of mutations. They usually contain encoding of proteins whose function is to inhibit cell differentiation, stimulate cell… read more here.
Keywords: proto oncogene; cancer; proto; identification ... See more keywords
The proto-oncogene SRC phosphorylates cGAS to inhibit an anti-tumor immune response.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.167270
Abstract: cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an anti-tumor immune response. Recent studies reveal cGAS is frequently inhibited in cancer, and therapeutic targets to promote anti-tumor cGAS function remain elusive.… read more here.
Keywords: proto oncogene; anti tumor; src; tumor immune ... See more keywords
Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC
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DOI: 10.3390/cancers14040930
Abstract: Simple Summary The proto-oncogene PELP1 is commonly overexpressed in many cancers including triple negative breast cancer (TNBC). In this study, we utilized global proteomic and RNA-seq approaches to elucidate the molecular mechanisms by which PELP1… read more here.
Keywords: ribosomal proteins; expression; pelp1; tnbc ... See more keywords