Protocatechuic acid reverses myocardial infarction mediated by β‐adrenergic agonist via regulation of Nrf2/HO‐1 pathway, inflammatory, apoptotic, and fibrotic events
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23270
Abstract: Myocardial infarction (MI) is an instant ischemic death of cardiomyocytes that remains a major global cause of mortalities. MI is accompanied by oxidative, inflammatory, apoptotic, and fibrotic insults. Protocatechuic acid (PCA) is a polyphenolic compound… read more here.
Keywords: apoptotic fibrotic; protocatechuic acid; inflammatory apoptotic; factor ... See more keywords
Protocatechuic acid mitigates adriamycin-induced reproductive toxicities and hepatocellular damage in rats
Sign Up to like & getrecommendations! Published in 2018 at "Comparative Clinical Pathology"
DOI: 10.1007/s00580-018-2794-2
Abstract: Adriamycin (ADR) is an anticancer drug that has a wide report of toxicity in various organs including testes and liver. This has brought limitation to its use in chemotherapy. Protocatechuic acid (PCA) is a phenolic… read more here.
Keywords: group; protocatechuic acid; testes liver; adr induced ... See more keywords
The effect of protocatechuic acid on the phycosphere in harmful algal bloom species Scrippsiella trochoidea.
Sign Up to like & getrecommendations! Published in 2020 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2020.105591
Abstract: The effects of allelopathy and the potential harm of several isolated allelochemicals have been studied in detail. Microorganisms in the phycosphere play an important role in algal growth, decay and nutrient cycling. However, it is… read more here.
Keywords: effect; control groups; scrippsiella trochoidea; protocatechuic acid ... See more keywords
Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies
Sign Up to like & getrecommendations! Published in 2019 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2019.06.001
Abstract: Abstract A series of 15 novel 1,3,4-thiadiazole amide derivatives containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino (4) and amino (5) analogues of a phenyl-substituted 1,3,4-thiadiazole amide derivative… read more here.
Keywords: novel thiadiazole; protocatechuic acid; conjugates derived; derived protocatechuic ... See more keywords
Protocatechuic acid inhibits TGF-β1-induced proliferation and migration of human airway smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2018.10.011
Abstract: Protocatechuic acid (3, 4-dihydroxybenzoic acid, PCA) is a major metabolite of anthocyanins and was reported to possess anti-allergic response. However, the effects of PCA on airway smooth muscle cells (ASMCs) proliferation and migration remain unclear.… read more here.
Keywords: proliferation migration; protocatechuic acid; proliferation; migration ... See more keywords
Protocatechuic acid-metal-nicotine complexation study for chelation of smoking-related poisoning
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.113428
Abstract: Abstract Nephropathy in tobacco smoker is postulated to be caused by nicotine (Nic) and catalyzed by various heavy metals (M(II) = Ni(II), Pb(II), and Cd(II)) contained in commercial cigarettes. Once absorbed through the lungs, these compounds will… read more here.
Keywords: chelation; nic heavy; study; protocatechuic acid ... See more keywords
Protocatechuic Acid Ameliorated Palmitic-Acid-Induced Oxidative Damage in Endothelial Cells through Activating Endogenous Antioxidant Enzymes via an Adenosine-Monophosphate-Activated-Protein-Kinase-Dependent Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b03414
Abstract: Protocatechuic acid (PCA, 3,4-dihydroxybenzoic acid), the main metabolite of anthocyanins, is widely distributed in fruits and vegetables and has been reported to possess a strong antioxidant activity. Herein, we aimed to investigate the protective effect… read more here.
Keywords: oxidative damage; kinase; induced oxidative; protocatechuic acid ... See more keywords
Protocatechuic Acid-Ameliorated Endothelial Oxidative Stress through Regulating Acetylation Level via CD36/AMPK Pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b02647
Abstract: As one of the main metabolites of anthocyanin, protocatechuic acid (PCA) possesses strong antioxidant activity. In the present study, we explored the capacity of PCA on the alleviation of endothelial oxidative stress and investigated the… read more here.
Keywords: protocatechuic acid; endothelial oxidative; level; acid ... See more keywords
Protocatechuic Acid-Based Supramolecular Hydrogel Targets SerpinB9 to Achieve Local Chemotherapy for OSCC.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c07534
Abstract: Protocatechuic acid (PCA) is a natural phenolic acid present in daily vegetables and fruits. Notably, PCA was demonstrated to inhibit the biological function of SerpinB9 (Sb9) and exhibit an excellent antitumor effect, showing great potential… read more here.
Keywords: protocatechuic acid; supramolecular hydrogel; acid based; chemotherapy ... See more keywords
Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in rodents and humans
Sign Up to like & getrecommendations! Published in 2017 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2017.1354543
Abstract: Protocatechuic acid has very promising properties potentially useful in the inhibition of neurodegenerative diseases progression. It is the main metabolite of the complex polyphenolic compounds and is believed to be responsible for beneficial effects associated… read more here.
Keywords: vitro vivo; neurodegenerative diseases; protocatechuic acid; vivo studies ... See more keywords
Agglomerated serum albumin adsorbed protocatechuic acid coated superparamagnetic iron oxide nanoparticles as a theranostic agent
Sign Up to like & getrecommendations! Published in 2023 at "Nanotechnology"
DOI: 10.1088/1361-6528/acb15b
Abstract: Iron oxide nanoparticles have been one of the most widely used nanomaterials in biomedical applications. However, the incomplete understanding of the toxicity mechanisms limits their use in diagnosis and treatment processes. Many parameters are associated… read more here.
Keywords: protocatechuic acid; spectroscopy; agent; oxide nanoparticles ... See more keywords