Anti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model
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DOI: 10.1080/13880209.2022.2088809
Abstract: Abstract Context Protocatechuic aldehyde (PCA) is a natural product that has various benefits for fibrosis. Objective This study evaluated the effects of PCA on renal fibrosis. Materials and methods Epithelial–mesenchymal transition (EMT) was induced by… read more here.
Keywords: renal proximal; proximal tubular; pca; unilateral ureteral ... See more keywords
Protocatechuic Aldehyde Inhibits α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells via PKA/CREB-Associated MITF Downregulation
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DOI: 10.3390/ijms22083861
Abstract: Protocatechuic aldehyde (PA) is a naturally occurring phenolic compound that is a potent inhibitor of mushroom tyrosinase. However, the molecular mechanisms of the anti-melanogenesis activity of PA have not yet been reported. The aim of… read more here.
Keywords: msh induced; melanoma cells; protocatechuic aldehyde; tyrosinase ... See more keywords
β-Cyclodextrin Inclusion Complexes with Catechol-Containing Antioxidants Protocatechuic Aldehyde and Protocatechuic Acid—An Atomistic Perspective on Structural and Thermodynamic Stabilities
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DOI: 10.3390/molecules26123574
Abstract: Protocatechuic aldehyde (PCAL) and protocatechuic acid (PCAC) are catechol derivatives and have broad therapeutic effects associated with their antiradical activity. Their pharmacological and physicochemical properties have been improved via the cyclodextrin (CD) encapsulation. Because the… read more here.
Keywords: inclusion; pcac; protocatechuic acid; protocatechuic aldehyde ... See more keywords