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Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.09.050
Abstract: Structural mechanisms underlying the mechanical properties of fibrin fibers are elusive. We combined tensile testing of uncrosslinked fibrin polymers in vitro and in silico to explore their material properties. The experimental stress (σ) - strain…
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Keywords:
uncrosslinked fibrin;
rupture;
fibrin fibers;
protofibril ... See more keywords
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Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00277
Abstract: The amyloid beta (Aβ) fibrillar aggregate is the hallmark of Alzheimer's disease (AD). Disassembling preformed fibril or inhibiting Aβ aggregation is considered as a therapeutic strategy for AD. Increasing evidence shows that green tea extracts,…
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Keywords:
disrupting protofibril;
green tea;
tea extracts;
protofibril ... See more keywords
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Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b02672
Abstract: Aggregation of amyloid beta (Aβ) peptides leads to formation of fibrilar, soluble oligomers, and their deposition is a key event in progression of Alzheimer’s disease (AD). Recent experimental studies of Arg-Arg-7-amino-4-trifluoromethylcoumarin (RR-AFC) showed significant Aβ…
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Keywords:
alzheimer protofibril;
destabilization alzheimer;
molecular insights;
protofibril ... See more keywords
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Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.624302
Abstract: Aggregates of the microtubule associated tau protein are a major constituent of neurofibrillary lesions that define Alzheimer’s disease (AD) pathology. Increasing experimental evidence suggests that the spread of tau neurofibrillary tangles results from a prion-like…
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Keywords:
tau;
molecular dynamics;
alzheimer disease;
protofibril ... See more keywords