Articles with "protofibril" as a keyword



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Strength, Deformability and Toughness of Uncrosslinked Fibrin Fibers from Theoretical Reconstruction of Stress-Strain Curves.

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Published in 2021 at "Acta biomaterialia"

DOI: 10.1016/j.actbio.2021.09.050

Abstract: Structural mechanisms underlying the mechanical properties of fibrin fibers are elusive. We combined tensile testing of uncrosslinked fibrin polymers in vitro and in silico to explore their material properties. The experimental stress (σ) - strain… read more here.

Keywords: uncrosslinked fibrin; rupture; fibrin fibers; protofibril ... See more keywords
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Green Tea Extracts EGCG and EGC Display Distinct Mechanisms in Disrupting Aβ42 Protofibril.

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Published in 2020 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.0c00277

Abstract: The amyloid beta (Aβ) fibrillar aggregate is the hallmark of Alzheimer's disease (AD). Disassembling preformed fibril or inhibiting Aβ aggregation is considered as a therapeutic strategy for AD. Increasing evidence shows that green tea extracts,… read more here.

Keywords: disrupting protofibril; green tea; tea extracts; protofibril ... See more keywords
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Molecular Insights into Destabilization of Alzheimer’s Aβ Protofibril by Arginine Containing Short Peptides: A Molecular Modeling Approach

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Published in 2019 at "ACS Omega"

DOI: 10.1021/acsomega.8b02672

Abstract: Aggregation of amyloid beta (Aβ) peptides leads to formation of fibrilar, soluble oligomers, and their deposition is a key event in progression of Alzheimer’s disease (AD). Recent experimental studies of Arg-Arg-7-amino-4-trifluoromethylcoumarin (RR-AFC) showed significant Aβ… read more here.

Keywords: alzheimer protofibril; destabilization alzheimer; molecular insights; protofibril ... See more keywords
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Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer’s Disease Protofibril Core

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Published in 2021 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2021.624302

Abstract: Aggregates of the microtubule associated tau protein are a major constituent of neurofibrillary lesions that define Alzheimer’s disease (AD) pathology. Increasing experimental evidence suggests that the spread of tau neurofibrillary tangles results from a prion-like… read more here.

Keywords: tau; molecular dynamics; alzheimer disease; protofibril ... See more keywords