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   Articles with "proton channel" as a keyword



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The voltage-gated proton channel Hv1 plays a detrimental role in contusion spinal cord injury via extracellular acidosis-mediated neuroinflammation

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recommendations! Published in 2021 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2020.10.005

Abstract: Tissue acidosis is an important secondary injury process in the pathophysiology of traumatic spinal cord injury (SCI). To date, no studies have examined the role of proton extrusion as mechanism of pathological acidosis in SCI.… read more here.

Keywords: acidosis; proton channel; cord; tissue ... See more keywords
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Does Proton Conduction in the Voltage-Gated Proton Channel hHV1 Involve Grotthus Hopping via Acidic Residues?

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.899

Abstract: Does Proton Conduction in the Voltage-Gated Proton Channel hH(V)1 Involve Grotthus Hopping via Acidic Residues? read more here.

Keywords: proton channel; involve grotthus; conduction voltage; proton conduction ... See more keywords
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A Hyperpolarization-Activated Proton Channel in Zebrafish Sperm

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recommendations! Published in 2018 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2017.11.2096

Abstract: revealed association of hERG1a, hERG1b, and SCN5A mRNAs and their corresponding proteins hERG1a, hERG1b and NaV1.5, indicative of a cotranslational complex. Furthermore, the transcripts can be co-regulated in iPSC-CMs as indicated by a coordinate decrease… read more here.

Keywords: proton channel; activated proton; herg1a herg1b; zebrafish sperm ... See more keywords
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Structural Basis for Asymmetric Conductance of the Influenza M2 Proton Channel Investigated by Solid-State NMR Spectroscopy.

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recommendations! Published in 2017 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2017.05.015

Abstract: The influenza M2 protein forms an acid-activated proton channel that is essential for virus replication. The transmembrane H37 selects for protons under low external pH while W41 ensures proton conduction only from the N terminus… read more here.

Keywords: state; proton channel; h37; channel ... See more keywords
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The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel.

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recommendations! Published in 2018 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.02.006

Abstract: The molecular mechanism of transmembrane proton translocation in rotary motor ATPases is not fully understood. Here, we report the 3.5-Å resolution cryoEM structure of the lipid nanodisc-reconstituted Vo proton channel of the yeast vacuolar H+-ATPase,… read more here.

Keywords: proton channel; cryoem structure; nanodisc reconstituted; proton ... See more keywords
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A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel.

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recommendations! Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b00721

Abstract: The M2 protein is an important target for drugs in the fight against the influenza virus. Because of the emergence of resistance against antivirals directed toward the M2 proton channel, the search for new drugs… read more here.

Keywords: proton channel; inhibition; proton; robust proton ... See more keywords
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Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters.

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recommendations! Published in 2018 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.8b06741

Abstract: Water-mediated interactions play key roles in drug binding. In protein sites with sparse polar functionality, a small-molecule approach is often viewed as insufficient to achieve high affinity and specificity. Here we show that small molecules… read more here.

Keywords: hydrogen bonded; proton channel; bound inwardclosed; networks hydrogen ... See more keywords
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Cholesterol inhibits human voltage-gated proton channel hHv1

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2205420119

Abstract: Significance Our work identified membrane cholesterol as a new inhibitor of human voltage-gated proton channel hHv1. Using single-molecule fluorescence resonance energy transfer (smFRET), we further showed that cholesterol inhibits the hHv1 channel by stabilizing the… read more here.

Keywords: human voltage; voltage gated; proton channel; cholesterol ... See more keywords
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Na+-H+ exchanger and proton channel in heart failure associated with Becker and Duchenne muscular dystrophies.

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recommendations! Published in 2017 at "Canadian journal of physiology and pharmacology"

DOI: 10.1139/cjpp-2017-0265

Abstract: Cardiomyopathy is found in patients with Duchenne (DMD) and Becker (BMD) muscular dystrophies, which are linked muscle diseases caused by mutations in the dystrophin gene. Dystrophin defects are not limited to DMD but are also… read more here.

Keywords: proton channel; heart; becker; sodium ... See more keywords
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RNA-Seq Analyses Reveal Roles of the HVCN1 Proton Channel in Cardiac pH Homeostasis

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.860502

Abstract: The voltage-gated proton channel HVCN1 is a member of the voltage-gated ion channel family. HVCN1 channel controls acid extrusion and regulates pH homeostasis in various cell types. Recent evidence indicated that the HVCN1 channel was… read more here.

Keywords: channel; proton channel; hvcn1 cardiac; hvcn1 ... See more keywords
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From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus

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recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2021.796229

Abstract: With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the… read more here.

Keywords: mechanisms proton; proton conduction; proton channel; activation mechanisms ... See more keywords