Bacterial proton motive force as an unprecedented target to control antimicrobial resistance.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21946
Abstract: Novel antibacterial therapies are urgently required to tackle the increasing number of multidrugâresistant pathogens. Identification of new antimicrobial targets is critical to avoid possible crossâresistance issues. Bacterial proton motive force (PMF), an energetic pathway located… read more here.
Keywords: pmf; bacterial proton; proton motive; resistance ... See more keywords
SmpB down-regulates proton-motive force for the persister tolerance to aminoglycosides in Aeromonas veronii.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.052
Abstract: Bacterial persisters comprise a small fraction of phenotypically heterogeneous variants with transient capability for survival when exposed to high concentrations of antibiotic. In aquatic pathogenic bacteria Aeromonas veronii, Small Protein B (SmpB), the core factor… read more here.
Keywords: smpb regulates; motive force; persister; proton motive ... See more keywords
In vivo regulation of proton motive force during photosynthetic induction
Sign Up to like & getrecommendations! Published in 2018 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2018.01.001
Abstract: Abstract Thylakoid proton motive force (pmf) plays a central role in photosynthesis. However, the regulation of pmf during photosynthetic induction is not well known. In the present study, in order to investigate the importance of… read more here.
Keywords: photosynthetic induction; high light; cef; proton motive ... See more keywords
Proton Motive Force-Disrupting Antimycobacterial Guanylurea Polymer.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00902
Abstract: Mycobacterial infectious diseases, including tuberculosis (TB), severely threaten global public health. Nonreplicating Mycobacterium tuberculosis (Mtb) is extremely difficult to eradicate using current TB drugs that primarily act on replicating cells. Novel TB drugs acting on… read more here.
Keywords: motive force; disrupting antimycobacterial; proton motive; force disrupting ... See more keywords
Active Efflux Leads to Heterogeneous Dissipation of Proton Motive Force by Protonophores in Bacteria
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.00676-21
Abstract: Various toxic compounds disrupt bacterial physiology. While bacteria harbor defense mechanisms to mitigate the toxicity, these mechanisms are often coupled to the physiological state of the cells and become ineffective when the physiology is severely… read more here.
Keywords: proton motive; motive force; active efflux; force ... See more keywords
Heterogeneous Distribution of Proton Motive Force in Nonheritable Antibiotic Resistance
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.02384-22
Abstract: Bacterial cells with low PMF may survive antibiotic stress due to dormancy, which favors nonheritable resistance without genetic mutations or acquisitions. On the other hand, cells with high PMF are less tolerant, as PMF helps… read more here.
Keywords: pmf; motive force; pmf cells; high pmf ... See more keywords
Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007697
Abstract: Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant discrepancy between antibiotic efficacy in vitro and in vivo,… read more here.
Keywords: activity aminoglycoside; aminoglycoside antibiotics; host; proton motive ... See more keywords