The Thr45Gly substitution in yeast alcohol dehydrogenase substantially decreases catalysis, alters pH dependencies, and disrupts the proton relay system.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109650
Abstract: X-Ray crystallography shows that the hydroxyl group of Thr-45 in the fermentative alcohol dehydrogenase (ADH1) from Saccharomyces cerevisiae is hydrogen-bonded to the hydroxyl group of the alcohol bound to the catalytic zinc and is part… read more here.
Keywords: relay system; alcohol; proton relay;
Electrochemical Strategy for Proton Relay Installation Enhances the Activity of a Hydrogen Evolution Electrocatalyst.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06011
Abstract: A new method to install a proton relay that enhances the reactivity near an active catalytic site for H2 production is reported, afforded by the electrochemical reduction and protonation of one of the ligands in… read more here.
Keywords: proton; hydrogen evolution; proton relay;
Dissecting the Ultrafast Stepwise Bidirectional Proton Relay in a Blue-Light Photoreceptor.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10206
Abstract: Proton relays through H-bond networks are essential in realizing the functionality of protein machines such as in photosynthesis and photoreceptors. It has been challenging to dissect the rates and energetics of individual proton-transfer steps during… read more here.
Keywords: proton transfer; blue light; dissecting ultrafast; proton ... See more keywords
Influence of the proton relay spacer on hydrogen electrocatalysis by cobalt hangman porphyrins
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s108842462150067x
Abstract: A cobalt hangman porphyrin system with a phenyl spacer between the porphyrin ring and an internal carboxylic acid group as well as its non-hangman analogue were synthesized and utilized for the study of the proton-coupled… read more here.
Keywords: cobalt; hydrogen; proton; hangman ... See more keywords
Investigation of the proton relay system operative in human cystosolic aminopeptidase P
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0190816
Abstract: Aminopeptidase P, a metalloprotease, targets Xaa-Proline peptides for cleavage [1–4]. There are two forms of human AMPP, a membrane-bound form (hmAMPP) and a soluble cytosolic form (hcAMPP)[5]. Similar to the angiotensin-I-converting enzyme, AMPP plays an… read more here.
Keywords: relay system; guanidine; aminopeptidase; hcampp ... See more keywords