Evaluation of Proton Therapy Reirradiation for Patients With Recurrent Head and Neck Squamous Cell Carcinoma
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DOI: 10.1001/jamanetworkopen.2022.50607
Abstract: Key Points Question What are the outcomes of patients receiving proton therapy reirradiation for head and neck squamous cell carcinoma (HNSCC)? Findings This cohort study of 242 patients with HNSCC found 1-year local control of… read more here.
Keywords: therapy reirradiation; proton therapy; head neck; reirradiation ... See more keywords
Automation of Monte Carlo‐based treatment plan verification for proton therapy
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DOI: 10.1002/acm2.12923
Abstract: Abstract Purpose Independent calculations of proton therapy plans are an important quality control procedure in treatment planning. When using custom Monte Carlo (MC) models of the beamline, deploying the calculations can be laborious, time consuming,… read more here.
Keywords: automation; treatment; monte carlo; proton therapy ... See more keywords
Treatment‐planning approaches to intensity modulated proton therapy and the impact on dose‐weighted linear energy transfer
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DOI: 10.1002/acm2.13782
Abstract: Abstract Purpose We quantified the effect of various forward‐based treatment‐planning strategies in proton therapy on dose‐weighted linear energy transfer (LETd). By maintaining the dosimetric quality at a clinically acceptable level, we aimed to evaluate the… read more here.
Keywords: letd; treatment; proton therapy; treatment planning ... See more keywords
Validation of pencil beam scanning proton therapy with multi‐leaf collimator calculated by a commercial Monte Carlo dose engine
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DOI: 10.1002/acm2.13817
Abstract: Abstract This study aimed to evaluate the clinical beam commissioning results and lateral penumbra characteristics of our new pencil beam scanning (PBS) proton therapy using a multi‐leaf collimator (MLC) calculated by use of a commercial… read more here.
Keywords: collimator; multi leaf; beam; beam scanning ... See more keywords
Measurements of fetal dose with Mevion S250i proton therapy system with HYPERSCAN
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DOI: 10.1002/acm2.13957
Abstract: Abstract Purpose To characterize potential dose to the fetus for all modes of delivery (dynamic adaptive aperture, static adaptive aperture, and no adaptive aperture) for the Mevion S250i Proton Therapy System with HYPERSCAN and compare… read more here.
Keywords: system; aperture; proton therapy; mevion s250i ... See more keywords
Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET.
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DOI: 10.1002/acm2.14014
Abstract: INTRODUCTION Tumor hypoxia is associated with poor treatment outcome. Hypoxic regions are more radioresistant than well-oxygenated regions, as quantified by the oxygen enhancement ratio (OER). In optimization of proton therapy, including OER in addition to… read more here.
Keywords: proton; pet; proton therapy; oer optimization ... See more keywords
Design of a focused collimator for proton therapy spot scanning using Monte Carlo methods.
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DOI: 10.1002/mp.14139
Abstract: PURPOSE When designing a collimation system for pencil beam spot scanning proton therapy, a decision must be made whether or not to rotate, or focus, the collimator to match beamlet deflection as a function of… read more here.
Keywords: collimator; proton therapy; spot scanning;
Localization of anatomical changes in patients during proton therapy with in-beam PET monitoring: a Voxel-Based Morphometry approach exploiting Monte Carlo simulations.
Sign Up to like & getrecommendations! Published in 2021 at "Medical physics"
DOI: 10.1002/mp.15336
Abstract: PURPOSE In-beam Positron Emission Tomography (PET) is one of the modalities that can be used for in-vivo non-invasive treatment monitoring in proton therapy. Although PET monitoring has been frequently applied for this purpose, there is… read more here.
Keywords: pet; treatment; beam pet; proton therapy ... See more keywords
Beam properties within the momentum acceptance of a clinical gantry beamline for proton therapy
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DOI: 10.1002/mp.15449
Abstract: Abstract Purpose Energy changes in pencil beam scanning proton therapy can be a limiting factor in delivery time, hence, limiting patient throughput and the effectiveness of motion mitigation techniques requiring fast irradiation. In this study,… read more here.
Keywords: beam; proton therapy; energy; acceptance ... See more keywords
A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy
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DOI: 10.1002/mp.15459
Abstract: Abstract Purpose In ultrahigh dose rate radiotherapy, the FLASH effect can lead to substantially reduced healthy tissue damage without affecting tumor control. Although many studies show promising results, the underlying biological mechanisms and the relevant… read more here.
Keywords: flash effect; dose rate; flash; proton therapy ... See more keywords
Feasibility study of fast intensity-modulated proton therapy dose prediction method using deep neural networks for prostate cancer.
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DOI: 10.1002/mp.15702
Abstract: PURPOSE Compared to the pencil-beam algorithm, the Monte-Carlo (MC) algorithm is more accurate for dose calculation but time-consuming in proton therapy. To solve this problem, this study uses deep learning to provide fast 3D dose… read more here.
Keywords: prostate cancer; dose; prediction; proton therapy ... See more keywords