On the role of ubiquinone in the proton translocation mechanism of respiratory complex I
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14506
Abstract: Complex I converts oxidoreduction energy into a proton electrochemical gradient across the inner mitochondrial or bacterial cell membrane. This gradient is the primary source of energy for aerobic synthesis of ATP. Oxidation of reduced nicotinamide… read more here.
Keywords: proton translocation; translocation; role ubiquinone; membrane ... See more keywords
Introduction of protonic potential of Brønsted−Lowry acids and bases to the quantification of the energy of proton translocation and elucidation of oxidative phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2020.113909
Abstract: Abstract ATP synthesis in mitochondria is driven by the pH gradient between lipid membranes, and a proton-motive force (PMF) forms along the respiratory electron-transport chain. The reasons for these phenomena remain unclear. In an unbuffered… read more here.
Keywords: lowry acids; energy; proton translocation; energy proton ... See more keywords
Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.05.022
Abstract: The nicotinamide nucleotide transhydrogenase (TH) is an integral membrane enzyme that uses the proton-motive force to drive hydride transfer from NADH to NADP+ in bacteria and eukaryotes. Here we solved a 2.2-Å crystal structure of… read more here.
Keywords: structure; proton translocation; water molecules; membrane ... See more keywords
Dynamic Second Harmonic Imaging of Proton Translocation Through Water Needles in Lipid Membranes
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c02810
Abstract: Proton translocation through lipid membranes is a fundamental process in the field of biology. Several theoretical models have been developed and presented over the years to explain the phenomenon, yet the exact mechanism is still… read more here.
Keywords: proton; water; lipid membranes; second harmonic ... See more keywords
A leigh syndrome mutation perturbs long-range energy coupling in respiratory complex I
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d4sc04036h
Abstract: Respiratory complex I is a central enzyme of cellular energy metabolism that couples electron transfer with proton translocation across a biological membrane. In doing so, it powers oxidative phosphorylation that drives energy consuming processes. Mutations… read more here.
Keywords: respiratory complex; energy; electron transfer; mutation ... See more keywords