Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14611
Abstract: Human MutT homolog 1 (MTH1), also known as Nudix type motif 1 (NUDT1), hydrolyzes 8-oxo-dGTP and 2-oxo-dATP with broad substrate recognition and has attracted attention in anti-cancer therapeutics. Previous studies on MTH1 have proposed that… read more here.
Keywords: recognition; mth1; protonation; broad substrate ... See more keywords
Impact of Interfacial Proton Accumulation on Protonation in a Brownmillerite Oxide
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202410084
Abstract: Electrochemical protonation provides ways to control physical properties and even explore unprecedented phases of solid‐state materials. While how proton accumulation changes materials’ properties is investigated, how protonation of solids can be controlled and promoted remains… read more here.
Keywords: proton; proton accumulation; protonation; sco films ... See more keywords
Wide‐Gamut and Reversible Phosphorescence Tuning From Green to NIR in Carbon Dots via Acid‐Responsive Protonation‐Assembly Strategy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202523830
Abstract: The development of stimulus‐responsive room‐temperature phosphorescence (RTP) materials with wide color ranges is crucial but challenging. A new strategy that integrates acid‐triggered carbon dots (CDs) protonation and assembly to realize a wide color RTP variable… read more here.
Keywords: phosphorescence; rtp; carbon dots; protonation ... See more keywords
A Solid‐Solution with Asymmetric Ni‐O‐Cr Sites for Boosting Protonation toward Anodic Oxidation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Energy Materials"
DOI: 10.1002/aenm.202401501
Abstract: Replacing the slow protonation process of oxygen evolution reaction (OER) with the fast protonation of alcohol electro‐oxidation can decrease the driving potentials, thus improving overall efficiency of electrochemical devices. However, the formation of effective catalytic… read more here.
Keywords: solid solution; oxidation; protonation; asymmetric sites ... See more keywords
Hydrofunctionalization of Polyunsaturated Hydrocarbons via Palladium(0) π‐Lewis Base‐Mediated Protonation
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DOI: 10.1002/cctc.202501167
Abstract: Palladium(0)‐catalyzed asymmetric hydrofunctionalization of polyunsaturated hydrocarbons offers an atom‐economic and highly stereoselective strategy for the synthesis of chiral molecules. Traditionally, these transformations are initiated via well‐established mechanisms such as Pd─H insertion or ligand‐to‐ligand hydrogen transfer… read more here.
Keywords: hydrofunctionalization polyunsaturated; polyunsaturated hydrocarbons; lewis base; protonation ... See more keywords
Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β‐Tubulin
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700530
Abstract: Regulation of microtubule assembly by antimitotic agents is a potential therapeutic strategy for the treatment of cancer, parasite infections, and neurodegenerative diseases. One of these agents is nocodazole (NZ), which inhibits microtubule polymerization by binding… read more here.
Keywords: state; water molecules; binding tubulin; protonation ... See more keywords
Linker Independent Regioselective Protonation Triggered Detoxification of Sulfur Mustards with Smart Porous Organic Photopolymer.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202302045
Abstract: The development of efficient metal-free photocatalysts for the generation of reactive oxygen species (ROS) for sulfur mustard (HD) decontamination can play a vital role against the stockpiling of chemical warfare agents (CWAs). Herein, one novel… read more here.
Keywords: detoxification; regioselective protonation; protonation; independent regioselective ... See more keywords
Purine tautomeric preferences and bond-length alternation in relation with protonation-deprotonation and alkali metal cationization
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-020-4343-6
Abstract: Quantum chemical calculations were carried out for deprotonated ( P − ) and protonated purine ( PH + ) and for adducts with one alkali metal cation ( P − M + and PM +… read more here.
Keywords: alkali metal; protonation; cationization; protonation deprotonation ... See more keywords
Standard state free energies, not pKas, are ideal for describing small molecule protonation and tautomeric states
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-020-00280-7
Abstract: The pKa is the standard measure used to describe the aqueous proton affinity of a compound, indicating the proton concentration (pH) at which two protonation states (e.g. A− and AH) have equal free energy. However,… read more here.
Keywords: molecule; free energies; tautomeric states; protonation ... See more keywords
New DTPA-derived bis-naphthalenophanes: fluorescence, protonation, and complexation with aromatic amines
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-017-0742-4
Abstract: Two fluorescent, water-soluble bis-naphthalenophane isomers with six carboxylate arms, abbreviated as (bis-dtpa14nap)H6 and (bis-dtpa15nap)H6, were synthesized, which consist of two 1,4- or 1,5-substituted naphthalene rings interlinked by two diethylenetriaminepentaacetic (DTPA) chains through amide-linkages. Both DTPA-based… read more here.
Keywords: derived bis; dtpa derived; bis naphthalenophanes; new dtpa ... See more keywords
Thermodynamic Study on the Protonation and Na+, Ca2+, Mg2+-Complexation of a Biodegradable Chelant (HEIDA) at Different Ionic Strengths and Temperatures
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Solution Chemistry"
DOI: 10.1007/s10953-018-0734-z
Abstract: A potentiometric method has been used for the determination of the protonation constants of N-(2-hydroxyethyl)iminodiacetic acid (HEIDA or L) at various temperatures 283.15 ≤ T/K ≤ 383.15 and different ionic strengths of NaCl(aq), 0.12 ≤ I/mol·kg−1 ≤ 4.84. Ionic strength dependence parameters were… read more here.
Keywords: log; ca2 mg2; different ionic; protonation ... See more keywords